68325-77-9

Upstream product

• 1824-96-0 methyl xylofuranoside 
• 532-20-7 D-xylofuranose 
• 7045-40-1 Methyl 3,5-O-Isopropylidene-α-D-xylofuranoside 
• 122-04-3 4-nitro-benzoyl chloride 

Downstream Products

• 850179-99-6 methyl 3,5-anhydro-2-O-(4-nitrobenzoyl)-α-D-xylofuranoside 

Relevant academic research and scientific papers

Fluoroglycolactone synthesis method

The invention discloses a synthesis method of fluoro sugar lactone. According to the method, D-xylose is taken as a starting raw material, hydroxyl is protected to synthesize a lactonide compound intermediate, and then the fluoroglycolactone is obtained through the steps of stereo conversion of sugar cyclic alcohol, benzyl addition, methyl glycoside removal, hydroxyl oxidation and the like. The raw materials adopted by the synthesis method are simple, cheap and easy to obtain, each synthesis step is mild in condition, the treatment process is simple, the yield is relatively high, and new raw materials and synthesis ways are provided for design of fluorine-containing bioactive molecules.

Convenient preparation of 3,5-anhydro- and 2,5-anhydropentofuranosides, and 5,6-anhydro-D-glucofuranose by use of the Mitsunobu reaction

Methyl 3,5-anhydro-α-d-xylofuranosides are obtained by use of the Mitsunobu reaction from 2-O-protected methyl α-d-xylofuranosides, which are easily prepared from d-xylose. The Mitsunobu reaction of methyl 3-N-benzylamino-3-deoxy- and 3-azido-3-deoxyarabi