68326-56-7

Upstream product

• 83859-14-7 N,N-Dimethyl-N'-[1-((R)-toluene-4-sulfinylmethyl)-prop-(E)-ylidene]-hydrazine 
• 1519-39-7 (R)-methyl p-tolyl sulfoxide 
• 107-12-0 propiononitrile 
• 1517-82-4 (1R,2S,5R,SS)-(-)-menthyl p-toluenesulfinate 
• 29066-36-2 (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl propionate 
• 105-37-3 Ethyl propionate 

Downstream Products

• 136347-14-3 (S)-2-hydroxy-2-<<(4-methylphenyl)sulfenyl>methyl>butanamide 
• 136347-10-9 (S₂,R_S)-2-hydroxy-2-<<(4-methylphenyl)sulfinyl>methyl>butanenitrile 
• 136347-12-1 (R)-2-Hydroxy-2-((R)-toluene-4-sulfinylmethyl)-butyronitrile 
• 71925-83-2 (R,Rs)-1-(4-methylphenylsulfinyl)-2-butanol 
• 71899-72-4 (2S,R_S)-1-(p-tolylsulfinyl)butan-2-ol 

Relevant academic research and scientific papers

Highly enantiomeric purity conversion of α-sulfinyl oximes and α-sulfinyl hydrazones to the corresponding β-keto sulfoxides with butyltriphenylphosphonium periodate (BUTPPPI)

Butyltriphenylphosphonium periodate (Ph3P+BuIO 4-)1 is readily prepared as a white solid from butyltriphenylphosphonium chloride, performs conversion of α-sulfinyl oximes (2) and α-sulfinyl hydrazones (4) to the

A new and general synthesis of chiral β-ketosulfoxides by reaction of (+)-(R)-methyl p-tolyl sulfoxide with nitriles

The nitrile functional group is efficiently transformed into the β-ketosulfoxide moiety by reaction with the anion formed from (+)-(R)-methyl p-tolyl sulfoxide and aqueous acidic work-up of the reaction.

Highly Diastereoselective Hydrocyanation of β-Keto Sulfoxides: Synthesis of Enantiomerically Pure Cyanohydrin Derivatives

The reactions of chiral β-keto sulfoxides, R1-CO-CHR2-SOTol (R1 = Me, n-Pr, i-Pr, t-Bu, Ph; R2 = H, Me) with Et2AlCN yield the corresponding sulfinyl cyanohydrins with high yields (85-96percent) and de (>96perce

Reactions of chiral β-ketosulfoxides with Et2AlCN: Asymmetric synthesis of cyanohydrin derivatives

The reaction of chiral p-tolylsulfinylmethyl ketones (R-CO-CH2-SOTol, R=Ph, Et and t-Bu) with Et2AlCN, yields almost optically pure sulfinyl cyanohydrins (d.e. ≥ 96%). The reaction was quicker in the presence of ZnCl2, but

The Preparation of Optically Active β-Keto Sulfoxides by Means of an Enantiomer-differentiating Reaction of α-Lithio Aryl Methyl Sulfoxides with Chiral Carboxylates

The reaction of α-lithio aryl methyl sulfoxides with a limited amount of chiral carboxylates (R2-CO-O-R*) was found to be an enantiomer-differentiating reaction, affording the corresponding optically active β-keto sulfoxides (3), tog