68327-00-4Relevant academic research and scientific papers
Synthesis of a rigidified bicyclic AAZTA-like ligand and relaxometric characterization of its GdIII complex
Martinelli, Jonathan,Martorana, Enrico,Tei, Lorenzo
supporting information, (2020/11/04)
The synthesis of a novel constrained polydentate ligand CpAAZTA derived from the heptadentate polyaminocarboxylic ligand AAZTA (6-amino-6-methylperhydro-1,4-diazepine-N, N’,N’’,N’’-tetraacetic acid) in which the ethylene bridge of the 1,4-diazepine ring i
Chiral Titanium Coordination Assemblies: Robust Cooperative Self-Supported Catalysts for Asymmetric Ring Opening of meso-Epoxides with Aliphatic Amines
Sun, Zheming,Chen, Jiangbo,Liu, Yaoqi,Tu, Tao
, p. 494 - 505 (2017/02/10)
By utilizing the oxygen bridge in dimeric μ-oxo-titanium-salen complexes as an efficient cross-linkage, a series of robust chiral titanium coordination assemblies has been successfully fabricated with the ditopic bridging ligands derived from BINOL and salen derivatives via coordination polymerization, which are fully characterized by IR, elemental analysis, XRD and microscopic studies. Because of their insolubility in most organic solvents and water, these metal-organic assemblies can successfully function as robust self-supported chiral catalysts, allowing an asymmetric ring opening (ARO) of meso-epoxides with aliphatic amines. Remarkably, owing to the linkage effects and the cooperation of two kinds of chiral titanium moieties in the metal-organic assemblies, the self-supported chiral catalysts demonstrate extremely high stability. They not only show high tolerance towards various meso-epoxides and nucleophilic aliphatic amines, but also can be reused in more than 20 runs without obvious metal leaching and loss in yields and enantioselectivities. Furthermore, the self-supported catalyst accomplished a one-pot tandem olefin epoxidation and ARO of an epoxide sequence starting from the olefin, 30% hydrogen peroxide and benzylamine. In marked contrast, the reaction failed to work when using the two corresponding homogeneous catalysts under identical reaction conditions. Good yields and enantioselectivities were obtained by the robust self-supported catalyst, which clearly indicates the cooperative effects between two chiral moieties within the metal-organic assemblies. The two catalytic centers can perform their own duties without interference and this further supports our strategy for the self-supported catalyst design. (Figure presented.).
Substituted Imidazopyridines as HDM2 Inhibitors
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Paragraph 0816, (2014/07/08)
The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
Heterogeneous Lewis acid catalysis with self-organized polymeric rare earth arylsulfonates under solvent-free conditions
Furuno, Hiroshi,Ishida, Shuichi,Suzuki, Shoko,Hayano, Tetsuji,Onitsuka, Satoaki,Inanaga, Junji
experimental part, p. 1007 - 1018 (2010/10/03)
Polymeric rare earth arylsulfonates, easily prepared from rare earth triisopropoxides and biphenyl-4,4'-disulfonic acid (BPDSA) or 1,3,5-triphenylbenzene trisulfonic acid (TPTSA) in a self-organization manner, were found to work as an efficient heterogene
Resolution of racemic 2-aminocyclohexanol derivatives and their application as ligands in asymmetric catalysis
Schiffers, Ingo,Rantanen, Toni,Schmidt, Frank,Bergmans, Werner,Zani, Lorenzo,Bolm, Carsten
, p. 2320 - 2331 (2007/10/03)
A preparatively easy and efficient protocol for the resolution of racemic 2-aminocyclohexanol derivatives is described, delivering both enantiomers with >99% enantiomeric excess (ee) by sequential use of (R)- and (S)-mandelic acid. A simple aqueous workup procedure permits the isolation of the amino alcohols in analytically pure form and the almost quantitative recovery of mandelic acid. Debenzylation of enantiopure trans-2-(N-benzyl)amino-1- cyclohexanol by hydrogenation and subsequent derivatization give access to a broad variety of diversely substituted derivatives. Furthermore, the corresponding cis isomers are readily available. Applications of these optically active aminocyclohexanols in catalyzed asymmetric phenyl transfer reactions to benzaldehydes and transfer hydrogenations of aryl ketones lead to products with up to 96% ee.
Syntheses and X-Ray Crystal Structures of Tricyclic Ketones Containing Trans-Fused Azabicyclooctane Units
Mori, Miwako,Saitoh, Fumihiko,Uesaka, Noriaki,Okamura, Kimio,Date, Tadamasa
, p. 4993 - 4998 (2007/10/02)
Tricyclic ketones containing the trans-fused 3-azabicyclooctane framework were prepared from the reactions of dienes and Cp2ZrBu2, followed by treatment with carbon monoxide.The structures were confirmed by X-ray analysis.
