68339-45-7

Usage

Uses

Used in Organic Synthesis:
2-(Cyclohexylaminomethyl)pyridine serves as a crucial building block in the synthesis of various drugs, contributing to the development of new pharmaceutical agents.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2-(CYCLOHEXYLAMINOMETHYL)PYRIDINE is utilized for the synthesis of a range of medicinal products, highlighting its importance in drug discovery and development.
Used in Antimicrobial Applications:
2-(Cyclohexylaminomethyl)pyridine is known to exhibit antimicrobial properties, making it a candidate for further research and potential use as an antibacterial agent.
Used in Research and Development:
Ongoing studies are being conducted to explore the therapeutic potential and safety profile of 2-(cyclohexylaminomethyl)pyridine, with the aim of expanding its applications in medicine and healthcare.

InChI:InChI=1/C12H18N2/c1-2-6-11(7-3-1)14-10-12-8-4-5-9-13-12/h4-5,8-9,11,14H,1-3,6-7,10H2

Upstream product

• 108-91-8 cyclohexylamine 
• 1121-60-4 pyridine-2-carbaldehyde 
• 40468-85-7 N-[(1E)-pyridin-2-ylmethylidene]cyclohexanamine 

Downstream Products

• 1295578-63-0 N₂C₃H₂(CH₂N(C₆H₁₁)CH₂C₅H₄N)2 
• 620958-32-9 dichloro(N-cyclohexylaminomethyl-2-pyridyl)iron(II) 
• 114366-17-5 2-(N-cyclohexylaminomethyl)piperidine 

Relevant academic research and scientific papers

Chromotropism in halo-bridged dimers. Structural characterization of bis(μ-halo)bis(halo N-(pyridin-2-ylmethyl)cyclohexanamine copper(II))

Two dinuclear copper(II) complexes, [LCu(μ-Cl)Cl]2 (DMF) (1) and [LCu(μ-Br)Br]2 (2), with the bidentate ligand N-(pyridin-2-ylmethyl)cyclohexanamine, L, were synthesized and characterized by physicochemical and spectroscopic (IR, UV-vis) data. The crystal structural analysis of 1 shows that both copper(II) ions are in a distorted square pyramidal N2Cl3 environment with the apical position of the copper(II) being occupied by the bridging chloride anion which is equatorial to the other copper ion, forming a dimeric copper(II) complex. The chromotropic properties of both complexes, including solvato-, thermo-, and halochromism, were investigated. The complexes show reversible thermochromism in solution which is irreversible in the solid state. It was found that the solvatochromism is due to structural change followed by solvation of the vacant sites of the complexes. Their halochromic properties were studied in pH range of 1–11 by visible absorption spectroscopy. The color changes from blue to green and to colorless are due to deprotonation and protonation of the ligands.

PROCESS FOR PREPARING CONJUGATED DIENE (CO)POLYMERS IN THE PRESENCE OF A CATALYTIC SYSTEM COMPRISING A PYRIDYL IRON (III) COMPLEX

A process for preparing conjugated diene (co)polymers comprising polymerizing at least one conjugated diene in the presence of a catalytic system comprising: (a) at least one pyridyl iron (III) complex having general formula (I) or (II): wherein: —R1, R2, R3 and R4, identical or different, represent a hydrogen atom; or are selected from linear or branched, optionally halogenated C1-C20, preferably C1-C15, alkyl groups, optionally substituted cycloalkyl groups, optionally substituted aryl groups; —R5 represents a hydrogen atom, or is selected from linear or branched, optionally halogenated C1-C20, preferably C1-C15, alkyl groups, optionally substituted cycloalkyl groups, optionally substituted aryl groups; —X, identical or different, represent a halogen atom such as, for example, chlorine, bromine, iodine; or are selected from linear or branched C1-C20, preferably C1-C15, alkyl groups, —OCOR6 groups or —OR6 groups wherein R6 is selected from linear or branched C1-C20, preferably C1-C15, alkyl groups. —n is 3; (b) at least one co-catalyst selected from organo-aluminum derivatives, preferably from: (b1) aluminum compounds having general formula (III): Al(R7)(R8)(R9) (IIl) wherein R7 represents a hydrogen atom, or is selected from linear or branched C1-C20 alkyl groups, cycloalkyl groups, aryl groups, alkylaryl groups, arylalkyl groups, alkoxy groups; R8 and R9, identical or different, are selected from linear or branched C1-C20 alkyl groups, cycloalkyl groups, aryl groups, alkylaryl groups, arylalkyl groups; (b2) aluminoxanes having general formula (IV): (R10)2—Al—O—[-AI(R11)—O-]m-AI-(R12)2 (IV), wherein R10, R11 and R12, identical or different, represent a hydrogen atom, or a halogen atom such as chlorine, bromine, iodine, fluorine; or are selected from linear or branched C1-C20 alkyl groups, cycloalkyl groups, aryl groups, said groups being optionally substituted with one or more silicon or germanium atoms; and m is an integer ranging from 0 to 1000; (b3) partially hydrolyzed organo-aluminum derivatives; (b4) haloaluminum alkyls having general formula (V) or (VI): AI(R13)p(X′)3-p (V) AI2(R13)q(X′)3-q (VI) wherein p is 1 or 2; q is an integer ranging from 1 to 5; R13, identical or different, are selected from linear or branched C1-C20 alkyl groups; X′ represents a chlorine or bromine atom, preferably chlorine; provided that said co-catalyst (b) is not selected from organo-boron derivatives.

Synthesis and characterization of aminopyridine iron(ii) chloride catalysts for isoprene polymerization: Sterically controlled monomer enchainment

In this study, a series of 2-R-6-(1-(alkylamino)methyl)pyridine-iron complexes [alkyl: (CPh3) Fe1H; (CHPh2) Fe2H; (CHPh2) Fe3Me; (CHMePh) Fe4H; (CH2Ph) Fe5H; (CHMe2) Fe6H; (C6H11) Fe7H; (CH2(4-OMe)Ph) Fe8H; (CH2(4-CF3)Ph) Fe9H; (CH2(2,4,6-Me3)Ph) Fe10H; (CH2Ph) Fe11Me] were synthesized and well characterized by ATR-IR spectroscopy, HRMS spectroscopy and elemental analysis. In addition, Fe3Me, Fe4H, Fe7H and Fe11Me were characterized by X-ray diffraction analysis: Fe3Me and Fe11Me adopted distorted tetrahedral geometries in the solid state while Fe4H and Fe7H were found in dimeric or polymeric forms respectively in which chlorides acted as bridging ligands. The catalytic capacities of these iron complexes were investigated for isoprene polymerization. Upon activation with a MAO cocatalyst, the catalytic activities of complexes varied as a function of the steric and electronic influences of substituents. In general, the catalysts bearing the least steric groups and electron-withdrawing groups exhibited relatively high activities. An outstanding activity of 190.6 × 104 g·mol-1·h-1 was obtained by Fe5H [CH2Ph]. Moreover, changes in the steric hindrance around the metal center showed a notable effect on the selectivity of monomer enchainment. In particular, most of the polymers obtained by these complexes bearing flexible frameworks were in favor of 3,4-enchainment.

COPPER COMPLEX INCLUDING 2-AMINOPYRIDYL BASED LIGAND, CATALYST FOR POLYMERIZATION OF MONOMER HAVING A RING-TYPE ESTER GROUP, AND METHOD OF FORMING POLYMER USING THE CATALYST

The present invention relates to a copper complex containing a 2-aminopyridyl-based ligand, a catalyst for polymerizing a monomer having a cyclic ester group, and a method for producing a polymer using the same. More specifically, provided is a copper complex containing a 2-aminopyridyl-based ligand as a compound having a novel structure. The copper complex is represented by chemical formula 1. In the chemical formula 1, R refers to a cycloalkyl group, a furyl group, or an aryl group, and X refers to a halogen group. At least one hydrogen of R can be substituted or unsubstituted with an alkyl group.COPYRIGHT KIPO 2017

Copper(II) complexes containing N,N′-bidentate N-substituted N-(pyridin-2-ylmethyl)amine: Synthesis, structure and application towards polymerization of rac-lactide

The reaction between [CuCl2·2H2O] and N,N′-bidentate N-(pyridin-2-ylmethyl)amines (Ln= LA–LE) in methanol yielded new Cu(II) complexes; namely mononuclear [LACuCl2] and dinuclear

Photoreduction of imines. An environmentally friendly approach to obtain amines

The photoreduction of different imines to amines in alcoholic solvents is reported. The reduction involves a versatile and chemoselective methodology that is environmentally friendly in that it avoids the use of metal hydrides and other dangerous reducing agents.

Iron complexes bearing iminopyridine and aminopyridine ligands as catalysts for atom transfer radical polymerisation

A series of iron(II) complexes bearing iminopyridine and aminopyridine ligands with N-alkyl and N-aryl substituents has been synthesised. X-Ray crystal structures of n-propyl- and 2,6-diisopropylphenyl-iminopyridine derivatives reveal dinuclear structures

Compounds with Bridgehead Nitrogen 52 -NMR Spectra and Stereochemistry of the 2-Alkylperhydroimidazolopyridines

In contrast to perhydro-oxazolopyridine and perhydrothiazolopyridine, which adopt equilibria in CDCl3 solution at room temperature containing ca 70percent trans-fused conformers in equilibria with O- or S-inside cis-fused conformers, 2-alkylperhydroimidazolopyridines are found to adopt equilibria containing >98percent trans-fused conformers.Comparison of NMR parameters of 2-methylperhydroimidazolopyridine with those of the two isomers of 1,2-dimethylperhydroimidazolopyridine indicates an equilibrium for the former compound between the two trans-fused conformers, with ca 83percent of that conformation containing a transarrangement of nitrogen lone pairs of electrons.These observations are explained in terms of the generalized anomeric effect.KEY WORDS Perhydroimidazolopyridine Conformational equilibria 1H and 13C NMR