68345-67-5

Usage

Uses

Used in Pharmaceutical Industry:
6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE-1-ACETIC ACID is used as a key intermediate in the synthesis of 5-HT7 receptor antagonists for the treatment of CNS disorders. These antagonists can help regulate serotonin levels in the brain, which may provide therapeutic benefits for various neurological and psychiatric conditions.
In the synthesis of 5-HT7 receptor antagonists, 6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE-1-ACETIC ACID serves as a crucial building block, allowing for the development of new drugs that can target and modulate the activity of the 5-HT7 receptor. This can lead to improved treatment options for patients suffering from CNS disorders, such as depression, anxiety, and schizophrenia.

InChI:InChI=1/C13H17NO4/c1-17-11-5-8-3-4-14-10(7-13(15)16)9(8)6-12(11)18-2/h5-6,10,14H,3-4,7H2,1-2H3,(H,15,16)

Upstream product

• 3382-18-1 6,7-dimethoxy-3,4-dihydro-isoquinoline 
• 141-82-2 malonic acid 

Downstream Products

• 1050190-68-5 [6,7-dimethoxy-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroisoquinolin-1-yl]acetic acid 
• 1172366-78-7 methyl 6,7-dimethoxy-1,2,3,4-tetrahydro-1-isoquinolineacetate hydrochloride 
• 105400-88-2 1-(p-tolylsulfonyl)-5,6-dimethoxy-1,2,3,8a-tetrahydrocyclopentisoquinolin-7(8H)-one O-(p-tolylsulfonyl)oxime 
• 105400-93-9 1-(p-tolylsulfonyl)-5,6-dimethoxy-1,2,3,8a-tetrahydrocyclopentisoquinolin-7(8H)-one oxime 
• 105400-86-0 1-(p-tolylsulfonyl)-5,6-dimethoxy-1,2,3,8a-tetrahydrocyclopentisoquinolin-7(8H)-one 
• 92666-92-7 2-[6,7-Dimethoxy-2-(4-nitro-benzoyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-acetamide 
• 92666-88-1 2-[2-(4-Chloro-benzoyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinolin-1-yl]-acetamide 
• 92666-85-8 2-benzoyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-acetamide 
• 92666-90-5 2-[2-(3-Bromo-benzoyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinolin-1-yl]-acetamide 
• 92666-91-6 2-[6,7-Dimethoxy-2-(4-methoxy-benzoyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-acetamide 
• 92666-89-2 2-[2-(4-Bromo-benzoyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinolin-1-yl]-acetamide 
• 92666-93-8 2-{2-[2-(4-Chloro-phenyl)-acetyl]-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinolin-1-yl}-acetamide 
• 92666-86-9 2-[6,7-Dimethoxy-2-(4-methyl-benzoyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-acetamide 
• 92666-87-0 2-[6,7-Dimethoxy-2-(3-methyl-benzoyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-acetamide 

Relevant academic research and scientific papers

Synthesis of the Marine Alkaloids Aaptamine and Demethyloxyaaptamine and of the Parent Structure Didemethoxyaaptamine

The first synthesis of the novel marine alkaloids aaptamine and demethyloxyaaptamine is described, as well as the first synthesis of the parent heterocycle 1H-benzonaphthyridine (didemethoxyaaptamine).

The Reaction of 3,4-Dihydroisoquinolines With Malonic Acid and Its Derivatives

The reaction of various 3,4-dihydroisoquinolines with malonic acid gives the corresponding 1,2,3,4-tetrahydro-1-isoquinolineacetic acids in good yield, while the reaction with cyanoacetic acid and malonic acid half ethyl ester affords 1,2,3,4-tetrahydro-1