6836-18-6

Basic information

• Product Name: 4-(4-METHOXYPHENYL) BUTYL CHLORIDE
• Synonyms: 4-(4-METHOXYPHENYL) BUTYL CHLORIDE;4-(4-METHOXYPHENYL)
• CAS NO: 6836-18-6
• Molecular Formula: C₁₁H₁₃ClO₂
• Molecular Weight: 198.69
• Mol File: 6836-18-6.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 307.7 °C at 760 mmHg
• Flash Point: 114.5 °C
• Appearance: /
• Density: 1.132 g/cm³
• Vapor Pressure: 0.000711mmHg at 25°C
• Refractive Index: 1.515
• CAS DataBase Reference: 4-(4-METHOXYPHENYL) BUTYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-METHOXYPHENYL) BUTYL CHLORIDE(6836-18-6)
• EPA Substance Registry System: 4-(4-METHOXYPHENYL) BUTYL CHLORIDE(6836-18-6)

Safety Data

• Hazardous Substances Data: 6836-18-6(Hazardous Substances Data)

Usage

General Description

4-(4-Methoxyphenyl) butyl chloride, also known as butyl 4-(4-methoxyphenyl) chloride, is a chemical compound with the formula C11H15ClO. It is a colorless liquid that is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. The presence of a butyl chain and a chlorine atom make it a versatile building block for organic chemistry, as it can undergo various reactions to form different compounds. It is important to handle this chemical with care, as it is considered to be toxic if ingested and can cause irritation to the skin, eyes, and respiratory system upon contact.

InChI:InChI=1/C11H13ClO2/c1-14-10-7-5-9(6-8-10)3-2-4-11(12)13/h5-8H,2-4H2,1H3

Upstream product

• 26153-41-3 γ-(4-methoxyphenyl)-γ-butyrolactone 
• 4521-28-2 4-(4-Methoxyphenyl)butyric acid 

Downstream Products

• 5701-83-7 1,4-bis(4-methoxyphenyl)butane 
• 187269-85-8 1,4-bis-[3-(3-carbomethoxymethylphenyl)-4-hydroxyphenyl]butane 
• 187269-83-6 1,4-bis-[3-(3-carbomethoxymethylphenyl)-(4-methoxy)phenyl]butane 
• 187269-88-1 1,4-bis-[3-(3-carbomethoxymethylphenyl)-4-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyloxy)phenyl]butane 
• 1314858-00-8 (R)-5-(4-methoxyphenyl)pyrrolidin-2-one 
• 1314842-85-7 (S)-5-(4-methoxyphenyl)pyrrolidin-2-one 
• 128100-35-6 5-(4-methoxyphenyl)pyrrolidin-2-one 
• 1073371-72-8 3-(3-(4-methoxyphenyl)propyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1111702-22-7 N-(4,4-diethoxybutyl)-4-(4-methoxyphenyl)-butyramide 
• 132944-93-5 N-(4-p-methoxyphenylbutyryl)-L-prolinal diethyl acetal 

Relevant articles and documents

Photoinduced Aerobic Iodoarene-Catalyzed Spirocyclization of N-Oxy-amides to N-Fused Spirolactams**

Iodoarene catalysis is a powerful methodology that usually requires an excess of oxidant, or of redox mediator if the terminal oxidant is dioxygen, to generate the key hypervalent iodine intermediate to proceed efficiently. We report that, using the spiro-cyclization of amides as a benchmark reaction, aerobic iodoarene catalysis can be enabled by relying on a pyrylium photocatalyst under blue light irradiation. This unprecedented dual organocatalytic system allows the use of low catalytic loading of both catalysts under very mild operating conditions.

Green synthesis method of medical intermediate benzocyclohexanone compound

The invention provides a green synthesis method of a benzocyclohexanone compound, and belongs to the technical field of organic synthesis. The method provided by the invention comprises the followingsteps: by taking 4-phenylbutyric acid as a raw material, firstly carrying out reflux reaction with oxalyl chloride in dichloromethane, carrying out vacuum evaporation to dryness to obtain a crude product of the 4-phenylbutyryl chloride compound, then dissolving the crude product in a solvent, adding a metal-doped modified molecular sieve catalyst to start reaction, and stirring the solution at different temperatures to carry out ring closing reaction, thereby obtaining the product; and after the reaction is finished, carrying out suction filtration, solvent washing, column chromatography purification and other operations to obtain the target product benzocyclohexanone compound. The synthesis method disclosed by the invention is environment-friendly in reaction and simple and convenient tooperate, the catalyst can be recycled, and the synthesis method is suitable for green synthesis of the benzocyclohexanone compound.

Ruthenium(II)-Catalyzed Enantioselective γ-Lactams Formation by Intramolecular C-H Amidation of 1,4,2-Dioxazol-5-ones

We report the Ru-catalyzed enantioselective annulation of 1,4,2-dioxazol-5-ones to furnish γ-lactams in up to 97% yield and 98% ee via intramolecular carbonylnitrene C - H insertion. By employing chiral diphenylethylene diamine (dpen) as ligands bearing electron-withdrawing arylsulfonyl substituents, the reactions occur with remarkable chemo- and enantioselectivities; the competing Curtius-type rearrangement was largely suppressed. Enantioselective nitrene insertion to allylic/propargylic C - H bonds was also achieved with remarkable tolerance to the C=C and C=C bonds.