128100-35-6

Basic information

• Product Name: 2-Pyrrolidinone, 5-(4-methoxyphenyl)-
• CAS NO: 128100-35-6
• Molecular Weight: 191.23
• Mol File: 128100-35-6.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 2-Pyrrolidinone, 5-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrrolidinone, 5-(4-methoxyphenyl)-(128100-35-6)
• EPA Substance Registry System: 2-Pyrrolidinone, 5-(4-methoxyphenyl)-(128100-35-6)

Safety Data

• Hazardous Substances Data: 128100-35-6(Hazardous Substances Data)

Usage

General Description

2-Pyrrolidinone, 5-(4-methoxyphenyl)- is a chemical compound that belongs to the class of pyrrolidinone derivatives. It is also known by its chemical formula C11H13NO2. 2-Pyrrolidinone, 5-(4-methoxyphenyl)- consists of a pyrrolidinone ring with a 4-methoxyphenyl group attached to the fifth position. It is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals, agrochemicals, and other fine chemicals. Due to its diverse applications, 2-Pyrrolidinone, 5-(4-methoxyphenyl)- is of interest to researchers and manufacturers in the chemical industry.

Upstream product

• 65076-36-0 4-amino-4-(4-fluorophenyl)butanoic acid 
• 3153-44-4 4-(4-methoxy-phenyl)-4-oxo-butyric acid 
• 100-66-3 methoxybenzene 
• 149-87-1 Pyroglutamic acid 
• 51229-88-0 4-hydroxypentanonitrile 
• 5447-74-5 methyl 3-(4-methoxybenzoyl)propionate 
• 98-79-3 L-Pyroglutamic acid 
• 6836-18-6 4-(4-methoxyphenyl) butanoyl chloride 
• 4521-28-2 4-(4-Methoxyphenyl)butyric acid 
• 1749-08-2 N-(4-methoxy benzylidene)-4-methoxyaniline 

Downstream Products

• 207989-87-5 5-(4-hydroxy-phenyl)-pyrrolidin-2-one 
• 74190-66-2 2-(4-methoxyphenyl)pyrrolidine 
• 339087-31-9 4-(5-oxopyrrolidin-2-yl)benzonitrile 
• 899808-41-4 4-carboxymethyl-2-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 899808-35-6 5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester 
• 899808-30-1 2-oxo-5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester 
• 899808-36-7 5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 
• 899808-40-3 4-cyanomethyl-2-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 899808-39-0 4-iodomethyl-2-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 899808-37-8 4-hydroxymethyl-2-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 899808-29-8 2-oxo-5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 899808-31-2 2-oxo-5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-3-carboxylic acid ethyl ester 
• 899808-33-4 5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-3-carboxylic acid ethyl ester 
• 899808-28-7 5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidin-2-one 

Relevant articles and documents

Tropylium-promoted Ritter reactions

The Ritter reaction used to be one of the most powerful synthetic tools to functionalize alcohols and nitriles, providing valuableN-alkyl amide products. However, this reaction has not been frequently used in modern organic synthesis due to its employment of strongly acidic and harsh reaction conditions, which often lead to complicated side reactions. Herein, we report the development of a new method using salts of the tropylium ion to promote the Ritter reaction. This method works well on a range of alcohol and nitrile substrates, giving the corresponding products in good to excellent yields. This reaction protocol is amenable to microwave and continuous flow reactors, offering an attractive opportunity for further applications in organic synthesis.

Synthesis of Lactams via Ir-Catalyzed C-H Amidation Involving Ir-Nitrene Intermediates

x-membered lactams were synthesized via either an amidation of sp3 C-H bonds or an electrophilic substitution of arenes via Ir-nitrene intermediates. With the employment of a readily available iridium catalyst in dichloromethane or hexafluoro-2-propanol, a wide range of lactams were synthesized in good to excellent yields with high selectivity.