6836-97-1

Usage

Uses

Used in Pharmaceutical Industry:
3-Phenyl-2-pyrrolidinone is used as a key intermediate in the synthesis of pharmaceuticals for its ability to form complex organic molecules that can be utilized in the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Phenyl-2-pyrrolidinone is employed as a building block for the creation of agrochemicals, contributing to the development of pesticides and other agricultural products.
Used in Polymer Production:
3-Phenyl-2-pyrrolidinone is used as a component in the production of polymers, where it contributes to the formation of polymer chains with specific properties for various applications.
Used in Dye Manufacturing:
This chemical compound is utilized in the manufacturing of dyes, where it plays a role in creating colorants for textiles, plastics, and other materials.
Used in Coating Industry:
3-Phenyl-2-pyrrolidinone is used in the production of coatings, where it helps in formulating coatings with desired characteristics such as durability, color, and resistance to environmental factors.
Used in Fine Chemicals Manufacturing:
As a versatile intermediate, 3-Phenyl-2-pyrrolidinone plays a crucial role in the synthesis of various fine chemicals, which are used in a wide range of applications across different industries.

InChI:InChI=1/C10H11NO/c12-10-9(6-7-11-10)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H,11,12)

Upstream product

• 7646-66-4 N-benzoylaziridine 
• 140-29-4 phenylacetonitrile 
• 101-41-7 benzeneacetic acid methyl ester 
• 6836-98-2 3-phenyldihydrofuran-2-one 
• 88970-65-4 β-(carbomethoxy)-β-phenylpropionitrile 
• 6837-27-0 (+/-)-1-benzyl-3-phenylpyrrolidin-2-one 
• 959701-65-6 4-azido-2-phenylbutanal 
• 83-13-6 diethyl 2-phenylmalonate 
• 137518-24-2 diethyl (2-chloroethyl)phenylmalonate 
• 147410-39-7 N-tert-butoxycarbonyloxy-3-phenylpropylamine 
• 79232-58-9 3-Phenyl-2-oxo-3-pyrrolidincarbonsaeure-ethylester 
• 92647-37-5 diethyl (2-cyanomethyl)-2-phenylpropanedioate 
• 167398-74-5 3-carboxy-3-phenylpyrrolidin-2-one 
• 201230-82-2 carbon monoxide 

Downstream Products

• 137518-28-6 N-propargyl-3-phenyl-2-pyrrolidone 
• 137518-29-7 N,3-dipropargyl-3-phenyl-2-pyrrolidinone 

Relevant academic research and scientific papers

Carbazole-containing amides and ureas: Discovery of cryptochrome modulators as antihyperglycemic agents

A series of novel carbazole-containing amides and ureas were synthesized. A structure–activity relationship study of these compounds led to the identification of potent cryptochrome modulators. Based on the desired pharmacokinetic/pharmacodynamic parameters and the results of efficacy studies in db/db mice, compound 50 was selected for further profiling.

Asymmetric Michael Addition Reaction of α-Aryl-Substituted Lactams Catalyzed by Chiral Quaternary Ammonium Salts Derived from Cinchona Alkaloids: A New Short Synthesis of (+)-Mesembrine

The enantioselective Michael addition reaction of α-aryl-substituted lactams with electron-deficient olefins was efficiently catalyzed using chiral quaternary ammonium salts derived from cinchona alkaloids. This method was highly useful for the construction of an all-carbon-substituted quaternary carbon stereogenic center at the α-position of lactams in good to high yields and with good enantiomeric excess and could be applied to the short synthesis of (+)-mesembrine.

CHEMICAL COMPOUNDS ACTING AS PERK INHIBITORS

The invention is directed to substituted pyrrolidinone derivatives. Specifically, the invention is directed to compounds according to Formula X: wherein R41, R42, R43, R44, R45, R46, and R47 are defined herein. The compounds of the invention are inhibitors of PERK and can be useful in the treatment of cancer and diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease, stroke, diabetes, Parkinson disease, Huntington's disease, Creutzfeldt- Jakob Disease, and related prion diseases, amyotrophic lateral sclerosis, myocardial infarction, neurodegeneration, cardiovascular disease, atherosclerosis, ocular diseases, and arrhythmias, more specifically cancers of the breast, colon, pancreas and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PERK activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Synthesis of 3,3-and 4,4-alkyl-phenyl-substituted pyrrolidin-2-one derivatives

Syntheses of 3,3-and 4,4-alkyl-phenyl-substituted pyrrolidin-2-one derivatives are described. The final compounds were obtained by the reductive cyclization of relevant cyanoalkanoate esters using NaBH4 and CoCl2.6H2O. The obtained pyrroIidin-2-one derivatives are pharmacophoric fragments for the synthesis of various biologically active compounds.

SUBSTITUTED 4-(1H-BENZIMIDAZOL-2-YL)[1,4]DIAZEPANES USEFUL FOR THE TREATMENT ALLERGIC DISEASES

The present invention relates to novel 4-(1H-benzimidazol-2-yl)[1,4] diazepane derivatives of formula (1): and stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.

Novel substituted 4-(1H-benzimidazol-2-yl) [1,4]diazepanes useful for the treatment of allergic diseases

The present invention relates to novel 4-(1H-benzimidazol-2-yl)[1,4]diazepane derivatives of formula and stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.

Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease

The present invention relates to novel 4-(1H-benzimidazol-2-yl)[1,4]diazepane derivatives of formula (1): and stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.

Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases

The present invention relates to novel substituted piperidine derivatives of formula (1), stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.

Substituted piperidines useful for the treatment of allergic diseases

The present invention relates to novel substituted piperidine derivatives of the formula STR1stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic diseases including: seasonal rhinitis, allergic rhinitis, and sinusitis.