127399-72-8

Basic information

• Product Name: 5-Benzyloxy-6-methoxy-1-indanone
• Synonyms: 2,3-Dihydro-6-methoxy-5-(phenylmethoxy)-1H-inden-1-one;5-Benzyloxy-6-methoxy-1-indanone
• CAS NO: 127399-72-8
• Molecular Formula: C₁₇H₁₆O₃
• Molecular Weight: 268.31
• Product Categories: Aromatics Compounds;Aromatics;Heterocycles;Aromatics, Heterocycles
• Mol File: 127399-72-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Solubility: Acetone, Chloroform, Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: 5-Benzyloxy-6-methoxy-1-indanone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Benzyloxy-6-methoxy-1-indanone(127399-72-8)
• EPA Substance Registry System: 5-Benzyloxy-6-methoxy-1-indanone(127399-72-8)

Safety Data

• Hazardous Substances Data: 127399-72-8(Hazardous Substances Data)

Usage

Chemical Properties

Tan Solid

Upstream product

• 1135-15-5 dihydroisoferulic acid 
• 2107-69-9 5,6-dimethoxy-1-indanone 
• 127399-78-4 5-hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 

Downstream Products

• 760992-27-6 5-(benzyloxy)-2-(4-bromobenzoyl)-6-methoxyindan-1-one 
• 68360-26-9 6-benzyloxy-7-methoxy-3,4-dihydro-2H-isoquinolin-1-one 
• 1064206-58-1 methyl 2-((7-methoxy-1-oxo-6-(sulfamoyloxy)-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoate 
• 1064202-00-1 2-((3-chlorophenyl)sulfonyl)-7-methoxy-6-(sulfamoyloxy)-3,4-dihydroisoquinolin-1(2H)-one 
• 1064201-98-4 7-methoxy-2-((4-methoxyphenyl)sulfonyl)-6-(sulfamoyloxy)-3,4-dihydroisoquinolin-1(2H)-one 
• 1064201-94-0 7-methoxy-2-((3-methoxyphenyl)sulfonyl)-6-(sulfamoyloxy)-3,4-dihydroisoquinolin-1(2H)-one 
• 1064201-93-9 7-methoxy-2-((2-methoxyphenyl)sulfonyl)-6-(sulfamoyloxy)-3,4-dihydroisoquinolin-1(2H)-one 
• 1064206-55-8 methyl 2-((6-hydroxy-7-methoxy-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoate 
• 1064201-91-7 6-hydroxy-7-methoxy-2-((3-chlorophenyl)sulfonyl)-3,4-dihydroisoquinolin-1(2H)-one 
• 1064201-88-2 6-hydroxy-7-methoxy-2-((4-methoxyphenyl)sulfonyl)-3,4-dihydroisoquinolin-1(2H)-one 
• 1064201-86-0 6-hydroxy-7-methoxy-2-((3-methoxyphenyl)sulfonyl)-3,4-dihydroisoquinolin-1(2H)-one 
• 1064201-84-8 6-hydroxy-7-methoxy-2-((2-methoxyphenyl)sulfonyl)-3,4-dihydroisoquinolin-1(2H)-one 
• 1064201-81-5 6-benzyloxy-7-methoxy-2-((3-chlorophenyl)sulfonyl)-3,4-dihydroisoquinolin-1(2H)-one 
• 1064201-79-1 6-benzyloxy-7-methoxy-2-((4-methoxyphenyl)sulfonyl)-3,4-dihydroisoquinolin-1(2H)-one 

Relevant articles and documents

Synthesis, anti-tubulin and antiproliferative SAR of steroidomimetic dihydroisoquinolinones

A SAR translation strategy adopted for the discovery of tetrahydroisoquinolinone (THIQ)-based steroidomimetic microtubule disruptors has been extended to dihydroisoquinolinone (DHIQ)-based compounds. A steroid A,B-ring-mimicking DHIQ core was connected to

ISOQUINOLINE AMINOPYRAZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CANCER

Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

Monomethyl Ether Derivatives of 7,8-Dihydroxy- and 8,9-Dihydroxy-4-n-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzoquinolines as Possible Products of Metabolism by Catechol-O-methyltransferase

In order to facilitate identification of possible metabolites arising from in vitro action of catechol-O-methyltransferase upon 7,8-dihydroxy- and 8,9-dihydroxy-4-n-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzoquinolines (11, 12), all four possible monomethyl ether derivatives have been synthesized.Incubation of 11 and 12 with the enzyme revealed that the 8,9-dihydroxy positional isomer 12 (which contains the dopamine moiety held in the β conformation) but not the 7,8-dihydroxy isomer 11 (which holds the dopamine moiety in the α conformation) was a substrate for theenzyme.The sole detectable product of 12 was 8-hydroxy-9-methoxy derivative 15 in which the "meta" hydroxy group of the dopamine moiety is etherified.