683774-02-9Relevant academic research and scientific papers
Synthesis, preliminary biological evaluation and molecular modeling of some new heterocyclic inhibitors of TACE
Sengupta, Prabal,Puri, Chetan S.,Chokshi, Hemant A.,Sheth, Chetana K.,Midha, Ajay S.,Chitturi, Trinadha Rao,Thennati, Rajamannar,Murumkar, Prashant R.,Yadav, Mange Ram
, p. 5549 - 5555 (2011/12/15)
Central heteroaryl ring analogues belonging to a series of potent hydroxamate TACE inhibitors were synthesized. The TACE inhibitory activities of these compounds were evaluated by in vitro WBA and in silico molecular modeling studies using crystal structure of human TACE. Compound 14 showed very good in vitro inhibition, supported by the in silico docking studies.
Total Synthesis of (-)-13-acetoxymodhephene and (+)-14-acetoxymodhephene
Lee, Hee-Yoon,Murugan, Ravichandran N.,Moon, Deuk Kyu
experimental part, p. 5028 - 5037 (2010/02/28)
Stereoselective epoxidation of [4.3.3]propellane 16 set the stage for the Lewis acid catalyzed stereospecific ring contraction to an oxygenated modhephene structure and eventually led to the total synthesis of (-)-13-acetoxymodhephene and (+)- 14-acetoxym
Enantioselective synthesis of (R)-1-azaspiro-[4.4]nonane-2,6-dione ethylene ketal, key chiral intermediate in the elaboration of (-)-cephalotaxine
Pizzonero, Mathieu,Dumas, Francoise,d'Angelo, Jean
, p. 31 - 37 (2007/10/03)
An enantioselective synthesis of (R)-1-azaspiro[4.4]nonane-2,6-dione ethylene ketal (4), chiral relay in the elaboration of (-)-cephalotaxine (1b), starting from (R)-1-(2-methoxycarbonylethyl)-2-oxo-cyclopentanecarboxylic acid methyl ester ((R)-10) (8 chemical operations, 26% overall yield, ee ≥ 95%) is described. The Curtius rearrangement of acyl azide (12) was used as the key strategic element to install with a perfect stereochemical fidelity and a high efficiency an α-nitrogen substituent at the quaternary carbon center in 10.
The asymmetric Michael-type alkylation of chiral β-enamino esters: Critical role of a benzyl ester group in the racemization of adducts
Pizzonero, Mathieu,Hendra, Frederic,Delarue-Cochin, Sandrine,Tran Huu-Dau, Marie-Elise,Dumas, Francoise,Cave, Christian,Nour, Mohammed,D'Angelo, Jean
, p. 3853 - 3857 (2007/10/03)
In contrast with keto diester (R)-10a bearing a methyl ester group at the quaternary carbon center, the benzyl ester analogue (R)-10a partially racemized during workup, thereby revealing that the nature of the ester group at the quaternary carbon center h
