68380-52-9

Upstream product

• 109-73-9 N-butylamine 
• 5334-43-0 5-Amino-4-cyano-1-phenylpyrazole 
• 5334-48-5 4-chloro-1-(phenyl)-1H-pyrazolo[3,4-d]pyrimidine 
• 50427-77-5 5-amino-1-phenyl-1H-pyrazole-4-carboxamide 
• 21314-17-0 1-phenyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one 

Relevant academic research and scientific papers

Synthesis of novel 2-alkyl-4-substituted-amino-pyrazolo[3,4-d]pyrimidines as new leads for anti-bacterial and anti-cancer activity

Treatment of 6-alkyl-1-phenyl-4-chloro-(1H)-pyrazolo[3,4-d]pyrimidines, with different amines afforded a series of compounds whose identity and purity were confirmed by spectral and analytical means. The compounds were tested for antibacterial activity against four organisms viz. Staphylococcus aureus (Gram positive), S. epidermidis (Gram positive), Bacillus subtilis (Gram positive), Escherichia coli (Gram negative) using amoxicillin as standard control. Compounds 4d, 6b, 6c have shown best antibacterial activity in the series. The antiproliferative activity was tested against human skin cancer cell line G361. The compounds 3d, 4d, 5b, 5d, 5e, 6c, 7a were found to be the best of the series and showed the activity at micromolar concentration.

The one-pot conversion of pyrimidinone derivatives into substituted pyrimidines using diphenylphosphinic chloride under a mild condition

Pyrimidinone derivatives reacted with diphenylphosphinic chloride followed by addition of nucleophiles to afford substituted pyrimidine derivatives at a mild temperature (20-66°C).