683811-72-5

Usage

Uses

Used in Pharmaceutical Industry:
1H-Indene-2-ethanol, 1-(4-chlorophenyl)-3-phenylis used as a building block for the synthesis of various important compounds due to its unique structure and reactivity. It plays a crucial role in the development of new pharmaceuticals, contributing to the advancement of drug discovery and therapeutic applications.
Used in Organic Chemistry:
In the field of organic chemistry, 1H-Indene-2-ethanol, 1-(4-chlorophenyl)-3-phenylis utilized for its reactivity and structural properties, enabling the synthesis of a wide range of organic compounds. Its versatility in reactions and potential for creating novel chemical entities makes it a valuable asset in organic synthesis.
Used in Medicinal Chemistry:
1H-Indene-2-ethanol, 1-(4-chlorophenyl)-3-phenylalso has potential applications in medicinal chemistry, where its unique structure can be leveraged to design and develop new therapeutic agents. Its reactivity and compatibility with various chemical groups make it a promising candidate for the creation of innovative pharmaceutical compounds with potential therapeutic benefits.

Upstream product

• 10229-11-5 4-phenyl-but-3-yn-1-ol 
• 104-88-1 4-chlorobenzaldehyde 
• 71-43-2 benzene 
• 7632-57-7 diphenylmethylenecyclopropene 

Relevant academic research and scientific papers

Synthesis of Indenes by a BF3·OEt2-Mediated, One-Pot Reaction of Aryl Homopropargyl Alcohols, Aldehydes, and Arenes

A new and efficient protocol to prepare indenes is reported. Assisted by boron trifluoride diethyl etherate, the one-pot reaction of aryl homopropargyl alcohols and aldehydes in the presence of arenes yielded indene derivatives. The reaction was studied with various substrates, which suggests a cascade reaction including a sequence of Prins, Friedel-Crafts, ring-opening reactions, and Friedel-Crafts to form three C-C bonds leading to indenes.

Synthesis of the indene, THF, and pyrrolidine skeletons by lewis acid mediated cycloaddition of methylenecyclopropanes with aldehydes, N-tosyl aldimines, and acetals

Methylenecyclopropanes (MCPs 1) react with aldehydes, N-tosyl aldimines, and acetals to give the corresponding indene. THE and pyrrolidine cyclo-addition products in the presence of BF2·'OEt2 under mild reaction conditions. Some special transformations of MCPs 1 with aldehydes have been reported in this paper. A plausible reaction mechanism has been discussed, which is based on a deuterium-labeling experiment and the Prins-type reaction mechanism.

Lewis acid-mediated cycloaddition of methylenecyclopropanes with aldehydes and imines: A facile access to indene, THF, and pyrrolidine Skeletons via Homoallylic Rearrangement Protocol

Methylenecyclopropanes (MCPs) 1 can react with aldehydes and aldimines to give the corresponding indene, THF, and pyrrolidine cycloaddition products in the presence of BF3·OEt2 under mild reaction conditions.