68395-81-3

Basic information

• Product Name: 2-Benzyl-5-phenyloxazole
• Synonyms: 2-Benzyl-5-phenyloxazole
• CAS NO: 68395-81-3
• Molecular Formula: C₁₆H₁₃NO
• Molecular Weight: 235.28052
• Mol File: 68395-81-3.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Benzyl-5-phenyloxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzyl-5-phenyloxazole(68395-81-3)
• EPA Substance Registry System: 2-Benzyl-5-phenyloxazole(68395-81-3)

Safety Data

• Hazardous Substances Data: 68395-81-3(Hazardous Substances Data)

Upstream product

• 140-29-4 phenylacetonitrile 
• 3282-32-4 2-diazo-acetophenone 
• 150-30-1 Phenylalanine 
• 536-74-3 phenylacetylene 
• 122-78-1 phenylacetaldehyde 
• 64-04-0 phenethylamine 
• 1006-68-4 5-phenyloxazole 
• 13326-10-8 benzyl methyl carbonate 
• 1078-60-0 2-benzyl-5(4H)-oxazolone 
• 71-43-2 benzene 
• 98-86-2 acetophenone 
• 1816-88-2 2-azido-1-phenylethan-1-one 
• 103-80-0 phenylacetyl chloride 
• 58294-84-1 N-(2-oxo-2-phenylethyl)-2-phenylacetamide 

Downstream Products

• 31970-74-8 phenyl(5-phenyloxazol-2-yl)methanone 

Relevant articles and documents

Synthesis of 2,5-Disubstituted Oxazoles from Arylacetylenes and α-Amino Acids through an i 2 /Cu(NO 3) 2 ?3H 2 O-Assisted Domino Sequence

A new strategy has been developed for the synthesis of 2,5-disubstituted oxazoles from easily available arylacetylenes and α-amino acids in the presence of Cu(NO 3) 2 ?3H 2 O and iodine. This reaction process involves the I 2 /Cu(NO 3) 2 ?3H 2 O-assisted transformation of arylacetylene to α-iodo acetophenone, Kornblum oxidation to phenylglyoxal, condensation to imine, decarboxylation/annulation/oxidation reaction sequence to approach 2,5-disubstituted oxazoles.

N-heterocyclic carbene-Pd(II)-1-methylimidazole complex catalyzed C-H bond benzylation of (benzo)oxazoles with benzyl chlorides

The first example of phosphine-free, NHC-Pd(II) complex catalyzed direct C-H bond benzylation of (benzo)oxazoles with benzyl chlorides was reported in this paper. Under the suitable conditions, all reactions worked well enough to give the desired C2-benzylated products in good to almost quantitative yields, providing a facile and straight pathway for the C-H bond benzylation of (benzo)oxazoles within short time.

Palladium-catalyzed direct benzylation of azoles with benzyl carbonates

"Chemical Equation Presented" The direct aromatic sp2 C-H benzylation of azole compounds with benzyl carbonates proceeds efficiently in the presence of a Pd2(dba)3/dppp catalyst system and KaOAc as a base to afford the corresponding diarylmethanes in good yields. In addition, the same palladium catalyst enables the direct benzylic sp3 C-H benzylation with the second benzyl carbonates without employing any external base.