68401-41-2Relevant academic research and scientific papers
&β-Lactamase-Stable Penicillins. Synthesis and Structure-Activity Relationships of (Z)-Alkyloxyimino Penicillins; Selection of BRL 44154
Brown, Pamela,Calvert, Stephen H.,Chapman, Pauline C. A.,Cosham, Suzanne C.,Eglington, A. John,et al.
, p. 881 - 891 (2007/10/02)
A series of (Z)-2-alkyloxyimino-2-(2-aminothiazol-4-yl)acetamidopenicillins has been prepared.New methodology has been developed to prepare tertiary alkyl oximes.High stability to β-lactamases and potent antibacterial activity have been achieved against Gram-positive and certain Gram-negative organisms.Activity against methicillin-resistant Staphylococcus aureus was an unexpected finding.The cyclopentyl analogue 4f, BRL 44154, has been selected for further study.
Aminothiazole substituted penicillins and antibacterial compositions thereof
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, (2008/06/13)
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt or in-vivo hydrolysable ester thereof: STR1 wherein R1 is hydrogen or an amino protecting group and R is substituted methyl; optionally substituted C2-12 alkyl, alkenyl or alkynyl; carbocyclyl; aryl or heterocyclyl. These compounds have antibacterial properties, and therefore are of use in the treatment of bacterial infections in humans and animals caused by a wide range of organisms.
