68420-93-9

Usage

Uses

Used in Pharmaceutical Industry:
6-Methyl-8-quinolinamine is used as an intermediate in the synthesis of various drugs and pharmaceuticals. Its unique chemical structure allows it to be a key component in the development of new medications with potential therapeutic benefits.
Used in Cancer Research:
6-Methyl-8-quinolinamine is studied for its potential anti-cancer properties. It may exhibit inhibitory effects on the growth and progression of certain types of cancer, making it a promising candidate for further research and development in oncology.
Used in Inflammation Management:
6-Methyl-8-quinolinamine has also been investigated for its potential anti-inflammatory properties. If proven effective, it could be used in the development of treatments for various inflammatory conditions, providing relief and improving the quality of life for affected individuals.
Used in Dye and Pigment Production:
6-Methyl-8-quinolinamine is utilized in the production of dyes and pigments, contributing to the coloration of various products in industries such as textiles, plastics, and paints.
Used in Chemical Synthesis:
As a key intermediate, 6-Methyl-8-quinolinamine plays a crucial role in the synthesis of other important chemical compounds. Its versatile chemical properties make it a valuable building block in the creation of new and innovative materials with a wide range of applications.

InChI:InChI=1/C10H10N2/c1-7-5-8-3-2-4-12-10(8)9(11)6-7/h2-6H,11H2,1H3

Upstream product

• 68420-92-8 6-methyl-8-nitroquinoline 
• 89-62-3 4-methyl-2-nitroaniline 
• 68527-67-3 6-bromo-8-nitroquinoline 
• 875-51-4 4-Bromo-2-nitroaniline 

Downstream Products

• 3002-78-6 5-methyl-1,10-phenanthroline 
• 20984-33-2 6-Methyl-8-hydroxyquinoline 
• 1616877-94-1 (E)-N-(5-cinnamyl-6-methylquinolin-8-yl)pivalamide 
• 1616877-96-3 (E)-N-(5-(3-(4-fluorophenyl)allyl)-6-methylquinolin-8-yl)pivalamide 
• 1616877-98-5 N-(6-methylquinolin-8-yl)pivalamide 

Relevant academic research and scientific papers

Visible Light-Promoted Photocatalytic C-5 Carboxylation of 8-Aminoquinoline Amides and Sulfonamides via a Single Electron Transfer Pathway

An efficient photocatalytic method was developed for the remote C5-H bond carboxylation of 8-aminoquinoline amide and sulfonamide derivatives. This methodology uses in situ generated ?CBr3 radical as a carboxylation agent with alcohol and is further extended to a variety of arenes and heteroarenes to synthesize the desired carboxylated product in moderate-to-good yields. The reaction proceeding through a single electron transfer pathway was established by a control experiment, and a butylated hydroxytoluene-trapped aryl radical cation intermediate in high-resolution mass spectrometry was identified.

HETEROARYL COMPOUNDS AS CXCR4 INHIBITORS, COMPOSITION AND METHOD USING THE SAME

The present disclosure provides heteroaryl compounds of Formula (I), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to the CXCR4 pathway.

Transition-Metal-Free Regioselective C–H Bond Fluorination of 8-Amidoquinolines with Selectfluor

A simple and efficient transition-metal-free protocol for the regioselective C–H bond fluorination of 8-aminoquinoline scaffolds with Selectfluor was developed. The reaction has a broad substrate scope and provides facile access to the corresponding C-5 f

Synthesis and in vitro evaluation of novel 8-aminoquinoline-pyrazolopyrimidine hybrids as potent antimalarial agents

In the search of novel chemotherapeutic agents for emerging drug resistant parasites, the hybridization approaches have successfully emerged as an efficient tool in malarial chemotherapy. Herein, a rational design and synthesis of novel 8-aminoquinoline and pyrazolopyrimidine hybrids and their antimalarial activity against wild type Plasmodium falciparum (Pf-NF54) and resistant strain (Pf-K1) is reported. The medicinal chemistry approach to expand the scope of this series resulted in an identification of potent compounds with nanomolar potency (best IC50 5-10 nM). Systematic structure activity relationship (SAR) studies revealed that pyrazolopyrimidine and 8-aminoquinoline ring are essential for achieving good P. falciparum potency. The docking study revealed that the compound 6 can retain some of the critical interactions within pfDHODH drug target.

Novel Sulfonaminoquinoline Hepcidin Antagonists

The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.

TRIPLE SUBSTITUTED PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES OR CONDITIONS, OR CANCER

The present invention relates to a new family of triple substituted phenantroline derivatives of formula (I), which are useful for the treatment or profilaxis of a neurodegenerative or haematological disease or condition or cancer, their use as a medicament, especially for treating a neurodegenerative or haematological disease or condition or cancer, and a pharmaceutical composition comprising the compounds.

Substituted 8-sulfonamidoquinolines

Certain sulfonamidoquinolines and metal complexes thereof both of which are soluble in essentially water-immiscible organic solvents. The sulfonamidoquinolines have the structural formula STR1 where the R, R1 and R2 groups and m and n are as defined in the specification and claims hereof. Solutions of the sulfonamidoquinolines and the metal complexes thereof in essentially water-immiscible organic solvents.