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Usage

Uses

Used in Hair Dye Industry:
PPDA is used as a colorant in hair dyes for its ability to produce dark shades. However, due to its classification as a skin sensitizer, it has raised concerns about allergic reactions in some individuals, leading to its ban in certain European countries.
Used in Rubber Industry:
In the production of black rubber materials, PPDA serves as a key component, contributing to the color and appearance of the final product.
Used in Photography:
PPDA is utilized as a developing agent in black and white photography, playing a crucial role in the development process of photographic images.
Used in Food and Textile Industries:
PPDA is employed as a dye in the production of certain food and textile products, imparting color and enhancing visual appeal. However, its use in these industries is subject to regulatory considerations due to potential health risks associated with long-term exposure.

Upstream product

• 84619-47-6 (2R,3S)-piperazine-2,3-dicarboxylic acid 
• 16331-53-6 phenanthrene-2-carbonyl chloride 
• 89601-09-2 Piperazine-2,3-dicarboxylic acid 
• 40452-20-8 phenanthrene-2-carboxylic acid 
• 1352453-98-5 (+)-1-(phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid (R)-(+)-1-phenylethylamine salt 
• 1352453-96-3 (-)-1-(phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid (S)-(-)-1-phenylethylamine salt 
• 46027-28-5 (2RS,3RS)-piperazine-2,3-dicarboxylic acid 
• 89-01-0 2,3-dicarboxypyrazine 

Downstream Products

• 858131-66-5 (+/-)-cis-PPDA 
• 858131-67-6 (+)-1-(phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid 

Relevant academic research and scientific papers

Piperazine-2,3-dicarboxylic acid derivatives as dual antagonists of NMDA and GluK1-containing kainate receptors

Competitive N-methyl-d-aspartate receptor (NMDAR) antagonists bind to the GluN2 subunit, of which there are four types (GluN2A-D). We report that some N1-substituted derivatives of cis-piperazine-2,3-dicarboxylic acid display improved relative

Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists

The binding site for competitive NMDA receptor antagonists is on the NR2 subunit, of which there are four types (NR2A-D). Typical antagonists such as (R)-AP5 have a subunit selectivity of NR2A > NR2B > NR2C > NR2D. The competitive NMDA receptor antagonist

Phenanthryl piperazinyl dicarboxylic acids as selective nmda receptor modulating agents

Disclosed are compounds of formula (I) wherein: L is (a) optionally substituted by replacement of one or more of the hydrogen atoms on the phenanthrene ring system by one or more groups other than hydrogen; A is CH2, SO2 or C=O; X is CO2H, PO3H2, PO2H2, PO2HR5, PO2HOR5, SO3H, SO2H, or tetrazole; and R1, R2, R3, R4 and R5 are independently selected from H, alkyl, alkenyl, alkynyl, aryl and aralkyl; or a pharmaceutically acceptable acid salt or base addition salt or an in vivo hydrolysable ester or amide thereof. Compounds of formula (I) are selective NMDA receptor modulating agents and, therefore, may be used to advantage in vitro in neuroassays and in vivo in the treatment of disorders of the CNS.