68451-93-4Relevant academic research and scientific papers
Highly efficient one-pot preparation of 1,2,4-oxadiazoles in the presence of diazabicycloundecene
Lukin, Kirill,Kishore, Vimal
, p. 256 - 261 (2014/02/14)
New highly efficient method for the cyclization of acylamidoximes in the presence of diazabicycloundecene was developed and incorporated into a general and practical one-pot synthesis of 1,2,4-oxadiazoles (11 examples, 85-97% yields).
An improved oxadiazole synthesis using peptide coupling reagents
Liang, Gui-Bai,Feng, Danqing D.
, p. 6627 - 6630 (2007/10/03)
Substituted 1,2,4-oxadiazoles were synthesized in good yields in a one pot procedure by condensation of the corresponding amidoxime with carboxylic acids in the presence of a peptide coupling reagent in diglyme, followed by heating the reaction mixture to 100°C for several hours.
SYNTHESIS, SPECTROSCOPIC STUDIES AND MOLECULAR ORBITAL CALCULATIONS OF O-ACYLBENZAMIDOXIMES
Srivastava, Rajendra M.,Ramos, Mozart N.,Mendes e Silva, Leda M.
, p. 845 - 850 (2007/10/02)
O-Acyl derivatives of benzamidoxime, 1a, and tolylamidoximes, 1b-g, have been prepared.Out of seven compounds, four (viz., 1b,c,e,f) are new.The structure of these compounds were determined with the aid of UV, IR and NMR spectra.Molecular orbital calculations have been performed using the CNDO/2 method in order to obtain more insight into the configuration and conformation of these molecules.Our results support the view that Z configuration at the C=N bond and the ap conformation at the N-O bond in the O-acyl derivatives are the most stable ones.
SYNTHESIS AND MASS SPECTRA OF AROYLBENZAMIDOXIMES
Varella, Evangelia A.,Micromastoras, Evangelos D.,Alexandrou, Nicholas E.,Exner, Otto
, p. 596 - 607 (2007/10/02)
The synthesis of several O-aroylbenzamidoximes I and of some N-aroyl (II) as well as of bis(aroyl)benzamidoximes (III) is described and their fragmentation pattern in the mass spectra is discussed.O- and N-Aroylbenzamidoximes are distinguished on the basis of their mass spectra since the O-derivatives afford the ion corresponding to the acid +. whereas the N-derivatives the ion corresponding to the amide +H>.
