68452-38-0 Usage
Carbazole derivative
It is a compound derived from the parent molecule carbazole, with modifications made to its structure.
Benzo[a]carbazole core
The central structure of the compound is based on the benzo[a]carbazole core, which is a fused system of a benzene ring and a carbazole ring.
Methyl group at the 11th position
A methyl group (-CH3) is attached to the 11th position of the benzo[a]carbazole core, which influences the compound's properties and reactivity.
Carbonyl group at the 1st and 4th (11thH) positions
Two carbonyl groups (C=O) are present in the structure, one at the 1st position and another at the 4th (11thH) position, contributing to the compound's reactivity and functional groups.
Use in synthesis of organic materials
The compound may be used as a building block or intermediate in the synthesis of various organic materials, such as polymers or other complex molecules.
Pharmaceutical research and drug development
11-methyl-1H-benzo[a]carbazole-1,4(11H)-dione may be studied for its potential applications in the pharmaceutical industry, including the development of new drugs or drug delivery systems.
Specific properties and potential applications
The specific properties and potential applications of the compound may vary depending on the context and intended use, such as its solubility, stability, and reactivity with other molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 68452-38-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,4,5 and 2 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 68452-38:
(7*6)+(6*8)+(5*4)+(4*5)+(3*2)+(2*3)+(1*8)=150
150 % 10 = 0
So 68452-38-0 is a valid CAS Registry Number.
68452-38-0Relevant academic research and scientific papers
Chemoproteomics of an indole-based quinone epoxide identifies druggable vulnerabilities in vancomycin-resistant staphylococcus aureus
Kulkarni, Amogh,Soni, Isha,Kelkar, Dhanashree S.,Dharmaraja, Allimuthu T.,Sankar, Rathinam K.,Beniwal, Gaurav,Rajendran, Abinaya,Tamhankar, Sharvari,Chopra, Sidharth,Kamat, Siddhesh S.,Chakrapani, Harinath
, p. 6785 - 6795 (2019/08/20)
The alarming global rise in fatalities from multidrug-resistant Staphylococcus aureus (S. aureus) infections has underscored a need to develop new therapies to address this epidemic. Chemoproteomics is valuable in identifying targets for new drugs in different human diseases including bacterial infections. Targeting functional cysteines is particularly attractive, as they serve critical catalytic functions that enable bacterial survival. Here, we report an indole-based quinone epoxide scaffold with a unique boat-like conformation that allows steric control in modulating thiol reactivity. We extensively characterize a lead compound (4a), which potently inhibits clinically derived vancomycin-resistant S. aureus. Leveraging diverse chemoproteomic platforms, we identify and biochemically validate important transcriptional factors as potent targets of 4a. Interestingly, each identified transcriptional factor has a conserved catalytic cysteine residue that confers antibiotic tolerance to these bacteria. Thus, the chemical tools and biological targets that we describe here prospect new therapeutic paradigms in combatting S. aureus infections.
