68455-15-2

Upstream product

• 112-53-8 1-dodecyl alcohol 
• 123-76-2 levulinic acid 
• 591-12-8 5-methyl-2-furanone 

Relevant academic research and scientific papers

Carbon nanotube/PTFE as a hybrid platform for lipase B fromCandida antarcticain transformation of α-angelica lactone into alkyl levulinates

In this work an enzymatic method for the synthesis of alkyl levulinates from α-angelica lactone has been reported for the first time. Lipase B fromCandida antarcticawas immobilizedviainterfacial activation on the surface of a hybrid support, consisting of commercially available multi-walled carbon nanotubes (MWCNTs) and polytetrafluoroethylene (PTFE). Among the biocatalysts with various contents of PTFE in the support, the CALB/MWCNT-PTFE (0.10 wt%) biocatalyst with 22.5 wt% CALB loading was determined as the most active one in the model synthesis of then-butyl levulinate in toluene.n-Butyl levulinate was obtained quantitively after 120 min of the reaction under the selected reaction conditions (2-fold molar excess ofn-butanol, 0.150 g of biocatalyst per 1 mmol of α-angelica lactone, 20 °C). The yield ofn-butyl levulinate was found to be higher than that in the presence of accurate amounts of sulfuric acid or Novozyme-435. Additionally, the unique stability of the developed biocatalyst was demonstrated over 6 reaction cycles at 20 °C. The biocatalyst remained stable over 3 reaction cycles at 60 °C as well. The essence of the proposed approach lies in the possibility to overcome the equilibrium limitations occurring in the conventional Fisher esterification. The activity of the elaborated hybrid biocatalyst in the reactions non-specific for lipases is a clear proof of the versatility of the novel system.

Method for synthesizing levulinate

The invention relates to a method for synthesizing levulinate. The method comprises the following step: catalyzing levulinic acid and alcohol to be subjected to esterification reaction by utilizing aloading type PDA-SO3H solid acid catalyst, so as to obtain the levulinate. According to the method provided by the invention, the loading type PDA-SO3H solid acid catalyst is used as the catalyst, canbe recycled and also can be used for more efficiently catalyzing the generation of the levulinate. The method directly takes the levulinic acid and the alcohol as raw materials and the levulinate issynthesized through one-step reaction; the selectivity of a product is higher than 99.9 percent and the yield is high; when the alcohol is enough, the conversion rate of the levulinic acid reaches 87percent or more.