68473-05-2

Usage

Chemical class

Pyrimidinecarbonitrile derivative

Functional groups

Methylthio group, phenylamino group

Usage

Organic synthesis, pharmaceutical research

Potential applications

Development of new drugs

Value for research

Studying effects of functional groups on chemical reactivity and biological activity

Possible future benefits

New uses and potential benefits in scientific and industrial applications

Upstream product

• 62-53-3 aniline 
• 124598-28-3 4-chloro-6-phenyl-2-(methylthio)-pyrimidine-5-carbonitrile 
• 98-80-6 phenylboronic acid 
• 97693-21-5 2-methylsulfanyl-6-oxo-4-phenyl-1,6-dihydropyrimidine-5-carbonitrile 

Relevant academic research and scientific papers

1,5- disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases

Novel substituted pyrimido[4,5-d]pyrimidin-2-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.

REACTIONS WITH 2-METHYLTHIOPYRIMIDINES, SYNTHESIS OF SOME NEW FUSED PYRIMIDINES

4-Chloro-2-methylthio -6-phenylpirimidine-5-carbonitrile (II) reacts with hydrazine hydrate to yield the 2,4-dihydrazino derivative (IIId).Compound IIId reacts with nitrous acid to give ditetrazolopyrimidine (VI) and with carbon disulphide to form pyrazolo-s-triazolopyrimidine (VII).The reaction of II with phenylhydrazine affords directly the pyrazolo-pyrimidinederivative (IV).Also, compound II reacts with anthranilic acid to form 2-methylthio-4-phenyl-6-(o-carboxyphenylamino)pyrimidine-5-carbonitrile IIIe) which can bee cyclised into 1-methylthio-10-oxo-3-phenyl-10-pyrimidoquinazoline-4-carbonitrile (IX) by heating with acetic anhydride.Key words: Methylthiopyrimidine; chloropyrimidine; hydrazinopyrimidine; pyrimidoquinazolinone.