97693-21-5Relevant academic research and scientific papers
Design, synthesis, and antihypertensive activity of new pyrimidine derivatives endowing new pharmacophores
Farghaly, Ahmed M.,AboulWafa, Omaima M.,Elshaier, Yaseen A. M.,Badawi, Waleed A.,Haridy, Haridy H.,Mubarak, Heba A. E.
, p. 360 - 379 (2019/02/03)
A new series of achiral pyrimidine derivatives based on nifedipine-like structure was designed and synthesized. These pyrimidyl derivatives contained hydrazine, hydrazones, acetohydrazide, differently substituted benzylidene functionalities, benzosulfohyd
Synthesis and Anti-HBV Activity of Novel Substituted Pyrimidine Glycosides and Their Acyclic Analogues
Hawata,El-Sayed,Abdel-Rahman, Adel A.-H.
, p. 1734 - 1744 (2018/11/10)
New aryl substituted uracil and thiouracil glycosides are synthesized by glycosylation at N1 in the pyrimidine nucleus using glycopyranosyl halides in basic medium. In addition C-linked hydrazinyl acyclic sugar derivatives exhibiting different
Vasoactive thiomethyl-pyrimidines: Promising drug candidates with vascular activity
De Andrade, Audrey N.,Araújo, Alice V.,Barbosa, Hugo B.W.,Wanderley, Almir G.,Malta, Oscar L.,Dos Anjos, Janaína V.
, p. 1266 - 1273 (2017/06/06)
Pyrimidines and their derivatives are present in various biologically active molecules. Most of the synthetic methods employed to achieve the pyrimidinone ring consist of two stages: The synthesis of a Michael intermediate from an aldehyde and an "active
Synthesis, antiplasmodial activity and mechanistic studies of pyrimidine-5-carbonitrile and quinoline hybrids
Kaur, Hardeep,Balzarini, Jan,De Kock, Carmen,Smith, Peter J.,Chibale, Kelly,Singh, Kamaljit
, p. 52 - 62 (2015/06/30)
Abstract A series of hybrids comprising of 5-cyanopyrimidine and quinoline moiety were synthesized and tested for in vitro antiplasmodial activity against NF54 and Dd2 strains of Plasmodium falciparum. Hybrid bearing m-nitrophenyl substituent at C-4 of py
Synthesis and antiviral activity of new substituted pyrimidine glycosides
Ramiz, Mahmoud M. M.,El-Sayed, Wael A.,Hagag, Ezzat,Abdel-Rahman, Adel A.-H.
experimental part, p. 1028 - 1038 (2011/11/29)
A number of N-substituted pyrimidine glycosides were synthesized by coupling reaction of the pyrimidine base with acetobromosugars followed by deprotection. The synthesized compounds were tested for their antiviral activity against Hepatitis B Virus (HBV). Plaque reduction infectivity assay was used to determine virus count reduction as a result of treatment with tested compounds which showed moderate to high anti viral activities.
Glycosylation of 2-thiouracil derivatives. A synthetic approach to 3- glycosyl-2,4-dioxypyrimidines
Khodair,Ibrahim,El Ashry
, p. 433 - 444 (2007/10/03)
Reaction of 6-aryl-5-cyano-2-thiouracils 2a-d with glycosyl halides 4a,b under alkaline conditions gave the respective bisglycosylated derivatives 5a- h. However, their deacetylation with ammonia in methanol caused a cleavage of the S-glycosyl residue and gave the N-3 glycosylated analogues 6a-h.
A One-Step Synthesis of 2-Methylthio-6-oxopyrimidine Derivatives: Preparation of Fused Pyrimidinones
Hussain, S. M.,El-Barbary, A. A.,Mansour, S. A.
, p. 169 - 171 (2007/10/02)
Condensation of a ternary mixture of ethyl cyanoacetate, S-methylisothiourea and aromatic aldehydes in pyridine afforded directly the 4-aryl-5-cyano-6-oxopyrimidines IV in good yields.Alkylation of IV with alkyl halides in alkaline medium yielded the 1-al
