68474-13-5Relevant academic research and scientific papers
AMINOESTER DERIVATIVES
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Page/Page column 63; 64, (2016/12/22)
The invention relates to novel compounds which are both phosphodiesterase 4 (PDE4) enzymeinhibitorsand muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
Potent cannabinergic indole analogues as radioiodinatable brain imaging agents for the CB1 cannabinoid receptor
Deng, Hongfeng,Gifford, Andrew N.,Zvonok, Alexander M.,Cui, Guangjian,Li, Xiuyan,Fan, Pusheng,Deschamps, Jeffrey R.,Flippen-Anderson, Judith L.,Gatley, S. John,Makriyannis, Alexandros
, p. 6386 - 6392 (2007/10/03)
A series of novel aminoalkylindoles was synthesized in an effort to develop compounds that are potent agonists at the CB1 cannabinoid receptor and that are also easily labeled with radioisotopes of iodine for biochemical and imaging studies. 2-Iodophenyl-
Antiinflammation agents
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, (2008/06/13)
Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.
Pleuromutilin derivatives as antimicrobials
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, (2008/06/13)
The present invention relates to pleuromutilin derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medical therapy, particularly antibacterial therapy.
3-pyridyloxymethyl heterocyclic ether compounds useful in controlling neurotransmitter release
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, (2008/06/13)
Novel heterocyclic ether compounds of the formula: STR1 wherein n, *, R1, R2, R3 and y are specifically defined, or pharmaceutically acceptable salts or prodrugs thereof, which are useful in selectively controlling neurotransmitter release; therapeutically-effective pharmaceutical compositions of these compounds; and use of said compositions to selectively control neurotransmitter release in mammals.
Search for Configurationally Stable, Aracemic α-Amino Organolithiums
Gawley, Robert E.,Zhang, Qianhui
, p. 6077 - 6088 (2007/10/02)
The search for configurationally stable α-amino carbanions has led to an interesting observation of differing reactivity of diastereomeric organolithiums and to the characterization of aracemic 2-lithio-N-methylpiperidine and 2-lithio-N-methylpyrrolidine as configurationally stable α-aminoorganolithiums.Details for the preparation of these and related α-lithioheterocycles, evaluation of their and configurational stability, and a preliminary evaluation of the stereoselevtivity of their reactions with electrophiles is presented. - Keywords: α-Amino organolithiums; α-amino carbaions; 2-lithiopiperidine; 2-lithiopyrrrolidine; configurationally stable carbanions.
