6848-73-3

Usage

Uses

Used in Fragrance and Flavor Industry:
1-(2,3-dimethoxyphenyl)-1-ethanol is used as a key component in the fragrance and flavor industry for its distinctive sweet, floral scent and taste, enhancing the sensory experience of various products.
Used in Pharmaceutical Applications:
1-(2,3-dimethoxyphenyl)-1-ethanol is used as an antioxidant for its potential to protect cells from oxidative stress, which is a significant factor in the development of many diseases.
Used in Treatment of Diabetic Complications:
In the medical field, 1-(2,3-dimethoxyphenyl)-1-ethanol is being investigated as a potential treatment for diabetic complications due to its pharmacological properties.
Used as a Chiral Building Block in Organic Synthesis:
1-(2,3-dimethoxyphenyl)-1-ethanol serves as a valuable chiral building block in organic synthesis, playing a crucial role in the development of new pharmaceuticals and other specialty chemicals.
Used in Insecticidal Applications:
1-(2,3-dimethoxyphenyl)-1-ethanol is also being studied for its potential insecticidal properties, which could lead to its use in the development of new pesticides or insect control methods.
Used in Anti-Cancer Research:
1-(2,3-dimethoxyphenyl)-1-ethanol is being explored for its possible anti-cancer properties, with the aim of identifying new therapeutic approaches to combat cancer.

Upstream product

• 917-64-6 methyl magnesium iodide 
• 86-51-1 2,3-dimethyoxybenzaldehyde 
• 917-54-4 methyllithium 
• 75-16-1 methylmagnesium bromide 
• 74-83-9 methyl bromide 

Downstream Products

• 103517-22-2 3-ethyl-1,2-dimethoxybenzene 
• 880547-13-7 1-(2-hydroxy-3-(methoxymethoxy)phenyl)ethan-1-one 
• 14755-98-7 3-<2,3-Dimethoxy-phenyl>-propenal 
• 23997-79-7 1-(2,3-dimethoxy-phenyl)-ethanone oxime 
• 859737-59-0 3-acetyl-4-benzenesulfonyloxy-5-methoxy-benzoic acid 
• 34809-90-0 3-acetyl-4-hydroxy-3-methoxybenzaldehyde 
• 2134-91-0 4-hydroxy-5-methoxyisophthalic acid 
• 703-98-0 1-(2-hydroxy-3-methoxyphenyl)ethanone 
• 13494-10-5 2',3'-dihydroxyacetophenone 
• 38480-94-3 2,3-dimethoxyacetophenone 

Relevant academic research and scientific papers

TRPML MODULATORS

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

Extensive structure modification on luteolin-cinnamic acid conjugates leading to BACE1 inhibitors with optimal pharmacological properties

BACE1 inhibitory conjugates derived from two natural products, luteolin (1) and p-hydroxy-cinnamic acid (2), were subjected to systematic structure modifications, including various positions in luteolin segment for conjugation, different linkers (length, bond variation), as well as various substitutions in cinnamic acid segment (various substituents on benzene, and replacement of benzene by heteroaromatics and cycloalkane). Optimal conjugates such as 7c and 7k were chosen on the basis of a series of bioassay data for further investigation.

Dihydropyrimidinones: Efficient one-pot green synthesis using Montmorillonite-KSF and evaluation of their cytotoxic activity

A simple, efficient, cost-effective, recyclable and green approach has been developed for the synthesis of new dihydropyrimidinone analogs via the Biginelli reaction. The methodology involves a multicomponent reaction catalyzed by "HPA-Montmorillonite-KSF"as a reusable and heterogeneous catalyst. This method gives an efficient and much improved modification of the original Biginelli reaction, in terms of yield and short reaction times under solvent free conditions. All the derivatives were subjected to cytotoxicity screening against a panel of four different human cancer cell lines viz. colon (Colo-205), prostate (PC-3), leukemia (THP-1) and lung (A549) to check their effect on percentage growth. MTT [3-(4,5-dimethylthiazol-yl)-diphenyl tetrazoliumbromide] cytotoxicity assay was employed to check IC50 values. Of the synthesized analogs, 16a showed the best activity with IC50 of 7.1 ± 0.8, 13.1 ± 1.4, 13.8 ± 0.9 and 14.7 ± 1.1 μM against lung (A549), leukemia (THP-1), prostate (PC-3) and colon (Colo-205) cancer lines, respectively. The 16a analog was further checked for its effect on cancer cell properties through clonogenic (colony formation) and scratch motility (wound healing) assays and thereby was found that it reduced both the colony formation and migratory properties of the lung cancer cell line (A549). Further, molecular docking studies were performed with 16a to show its binding mode. This journal is

Solvent Dependence of the Monomer–Dimer Equilibrium of Ketone-Substituted Triscatecholate Titanium(IV) Complexes

Hierarchical helicates based on ketone-substituted titanium(IV)triscatecholates show different monomer-dimer behavior depending on different solvents. The dimerization constants of a whole series of differently alkyl-substituted complexes is analyzed to show that the solvent has a very strong influence on the dimerization. Hereby, effects like solvophobicity/philicity, sterics, electronics of the substituents and weak side-chain—side-chain interactions seem to act in concert.

Hierarchical assembly of helicate-type dinuclear titanium(IV) complexes

The ligands 4-7-H2 were used in coordination studies with titanium(IV) and gallium(III) ions to obtain dimeric complexes Li 4[(4-7)6Ti2] and Li6[(4/5a) 6Ga2]. The X-ray crystal structures of Li 4[(4)6Ti2], Li4[(5b) 6Ti2], and Li4[(7a)6Ti2] could be obtained. While these complexes are triply lithium-bridged dimers in the solid state, a monomer/dimer equilibrium is observed in solution by NMR spectroscopy and ESI FT-ICR MS. The stability of the dimer is enhanced by high negative charges (Ti(IV) versus Ga(III)) of the monomers, when the carbonyl units are good donors (aldehydes versus ketones and esters), when the solvent does not efficiently solvate the bridging lithium ions (DMSO versus acetone), and when sterical hindrance is minimized (methyl versus primary and secondary carbon substituents). The dimer is thermodynamically favored by enthalpy as well as entropy. ESI FT-ICR mass spectrometry provides detailed insight into the mechanisms with which monomeric triscatecholate complexes as well as single catechol ligands exchange in the dimers. Tandem mass spectrometric experiments in the gas phase show the dimers to decompose either in a symmetric (Ti) or in an unsymmetric (Ga) fashion when collisionally activated. The differences between the Ti and Ga complexes can be attributed to different electronic properties and a charge-controlled reactivity of the ions in the gas phase. The complexes represent an excellent example for hierarchical self-assembly, in which two different noncovalent interactions of well balanced strengths bring together eleven individual components into one well-defined aggregate.

Benzopyran derivatives having leukotriene-antagonistic action

The present invention relates to novel 4-oxo-4H-1-benzopyran compounds containing benzyloxymethyl, 3-phenylpropyl, or other araliphatic substituents in their 8-position. These compounds show a leukotriene-antagonistic activity. The compounds are characterized by good oral adsorption. The compounds of the present invention may be used as anti-inflammatory and antiallergic medicaments, and in the treatment of cardiovascular diseases.