68497-63-2

Upstream product

• 1198-97-6 4-phenylpyrrolidin-2-one 
• 96-34-4 methyl chloroacetate 
• 106869-48-1 4-phenyl-1-(trimethylsilyl)-2-pyrrolidinone 
• 96-32-2 bromoacetic acid methyl ester 
• 3060-41-1 (±)-3-carboxy-2-phenylpropan-1-aminium chloride 
• 103-36-6 ethyl 3-phenyl-2-propenoate 

Downstream Products

• 132351-24-7 2-(2-oxo-4-phenylpyrrolidinomethyl)benmzimidazole 
• 68644-48-4 N-[2-(diethylamino)ethyl]-2-oxo-4-phenyl-1-pyrrolidineacetamide 
• 68497-64-3 N-[3-[bis(1-methylethyl)amino]propyl]-2-oxo-4-phenyl-1-pyrrolidineacetamide 
• 88981-74-2 cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-2-oxo-4-phenyl-1-pyrrolidineacetamide 
• 77472-70-9 (RS)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide 

Relevant academic research and scientific papers

Method for preparing phenyl piracetam

The invention discloses a method for preparing phenyl piracetam, and belongs to the field of compound preparing. The method includes the following steps that alkali, cinnamic acid alkyl ester and nitromethane are subjected to an addition reaction to obtain 4-nitryl-3-phenylbutyric acid alkyl ester; after nitryl of the 4-nitryl-3-phenylbutyric acid alkyl ester is reduced with a reducing agent, the reduced nitryl and carbonyl are cyclized, and 4-phenyl-2-pyrrolidone is obtained; alkali, haloacetic acid alkyl ester and the 4-phenyl-2-pyrrolidone are subjected to an alkylation reaction to obtain 4-phenyl-2-pyrrolidone-1-acetic acid alkyl ester; the 4-phenyl-2-pyrrolidone-1-acetic acid alkyl ester and ammonia gas are reacted to obtain the phenyl piracetam. The method has the advantages of being short in reaction step, high in atom utilization, more environmentally friendly, safe in operation, high in reaction yield and purity, beneficial for achieving industrialization an the like.

Pyrrolidineacetic acid esters

Lower alkyl 2-oxo-4-phenyl-1-pyrrolidineacetic acid esters which are useful as pharmacological agents, especially cognition activators, are disclosed. They can be produced by reacting 4-phenyl-2-pyrrolidinone with a lower alkyl haloacetate in the presence of a strong base.

N-(Substituted-aminoalkyl)-2-oxo-1-pyrrolidineacetamides

N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidineacetamides which are useful as pharmacological agents, especially cognition activators, are disclosed. They can be produced by reacting a 2-oxo-1-pyrrolidineacetate ester with an appropriate amine.