68498-26-0

Basic information

• Product Name: 3,N(4)-ethenodeoxycytidine
• Synonyms: 3,N(4)-ethenodeoxycytidine
• CAS NO: 68498-26-0
• Molecular Formula: C₁₁H₁₃N₃O₄
• Molecular Weight: 251.2386
• Mol File: 68498-26-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 608.8°Cat760mmHg
• Flash Point: 322°C
• Appearance: /
• Density: 1.68g/cm³
• Vapor Pressure: 1.13E-15mmHg at 25°C
• Refractive Index: 1.747
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• CAS DataBase Reference: 3,N(4)-ethenodeoxycytidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,N(4)-ethenodeoxycytidine(68498-26-0)
• EPA Substance Registry System: 3,N(4)-ethenodeoxycytidine(68498-26-0)

Safety Data

• Hazardous Substances Data: 68498-26-0(Hazardous Substances Data)

Usage

Uses

3,N4-Etheno-2’-deoxycytidine is a biomarkers for assessing oxidative stress. Formed in human white blood cells.

InChI:InChI=1/C11H13N3O4/c15-6-8-7(16)5-10(18-8)14-3-1-9-12-2-4-13(9)11(14)17/h1-4,7-8,10,15-16H,5-6H2/t7-,8+,10+/m0/s1

Upstream product

• 107-20-0 2-chloroethanal 
• 3992-42-5 2'-deoxycytidine monohydrochloride 
• 55662-66-3 [13C⁴,15N₃]-3,N⁴-ethenocytosine 
• 951-77-9 2'-Deoxycytidine 
• 2065-75-0 2-Bromo-malonaldehyde 

Downstream Products

• 136851-95-1 5'-O-(4,4'-dimethoxytrityl)-3,N⁴-etheno-2'-deoxycytidine 

Relevant articles and documents

An aza-nucleoside, fragment-like inhibitor of the DNA repair enzyme alkyladenine glycosylase (AAG)

The DNA repair enzyme AAG has been shown in mice to promote tissue necrosis in response to ischaemic reperfusion or treatment with alkylating agents. A chemical probe inhibitor is required for investigations of the biological mechanism causing this phenomenon and as a lead for drugs that are potentially protective against tissue damage from organ failure and transplantation, and alkylative chemotherapy. Herein, we describe the rationale behind the choice of arylmethylpyrrolidines as appropriate aza-nucleoside mimics for an inhibitor followed by their synthesis and the first use of a microplate-based assay for quantification of their inhibition of AAG. We finally report the discovery of an imidazol-4-ylmethylpyrrolidine as a fragment-sized, weak inhibitor of AAG.

Addition of deoxyribose to guanine and modified DNA bases by Lactobacillus helveticus trans-N-deoxyribosylase

The use of bacterial trans-N-deoxyribosylase was evaluated as an alternative method for deoxyribosylation in the synthesis of deoxyribonucleosides containing potentially mutagenic adducts. A crude enzyme preparation was isolated from Lactobacillus helveticus and compared to Escherichia coli purine nucleoside phosphorylase. trans-N-deoxyribosylase was more regioselective than purine nucleoside phosphorylase in the deoxyribosylation of Gua at the N9 atom, as compared to N7, as demonstrated by NMR analysis of the product. 5,6,7,9-Tetrahydro-7-acetoxy-9- oxoimidazo[1,2-a]purine was efficiently deoxyribosylated by trans-N- deoxyribosylase but not at all by purine nucleoside phosphorylase. Other substrates for trans-N-deoxyribosylase were N2-(2-oxoethyl)Gua, pyrimido[1,2-a]purin-10(3H)-one, 1,N2-ε-Gua, N2,3ε-Gua, 3,N4-(-Cyt, 1,N6-ε-Ade, C8-methylGua, and C8-aminoGua, most of which gave the desired isomer (bond at the nitrogen corresponding to N9 in Gua) in good yield. Neither N7-alkylpurines nor C8-(arylamino)-substituted guanines were substrates. The approach offers a relatively convenient method of enzymatic preparation of many carcinogen-DNA adducts at the nucleoside level, for either use as standards or incorporation into oligonucleotides. trans-N- deoxyribosylase can also be used to remove deoxyribose from modified deoxyribonucleosides in the presence of excess Cyt.