6857-88-1Relevant articles and documents
Photochemical reactions. 21. Sensitized photooxygenation of N-methylated 4-aza-5-androsten-3-one and 4-aza-5-androstene steroidal systems
Piniella,Estape,Lupon,et al.
, p. 3011 - 3016 (1987)
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Shielding effect of ether C-O bond obtained from proton chemical shifts of 4-oxa-5α- and 4-oxa-5β-androstan-17-ones
Yang, Yanyan,Haino, Takeharu,Usui, Shuji,Fukazawa, Yoshimasa
, p. 2325 - 2336 (1996)
4-Oxa-5α- and 4-oxa-5β-androstanones (1 and 2) were synthesized in order to obtained the NMR shielding parameters for the ether C-O bond. The complete NMR assignment of both the proton and carbon atoms for these compounds and substituent-induced shifts (SIS) from the corresponding androstanones (3 and 4) are presented. The comparison of the molecular structure obtained by MM3 calculation with that of X-ray crystallographic analysis disclosed that the former structure is completly superimposable to the latter in both of the compounds 1 and 2. A combination of the electric field effect and the anisotropy of the magnetic susceptibility of the C-O bond can successfully reproduce the observed SIS values for these androstanones.
CYP11B, CYP17, AND/OR CYP21 INHIBITORS
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Page/Page column 179, (2012/06/30)
Provided herein are inhibitors of CYP11B, CYP17, and/or CYP21 enzymes of Formula (Z), (IX), (X), (XI), (XII), (XIII), (XIV), (XV), (XVI), or (XVII). Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat androgen-dependent diseases, disorders and conditions. Formula (Z)
DECAHYDRO-1H-INDENOQUINOLINONE AND DECAHYDRO-3H-CYCLOPENTAPHENANTHRIDINONE CYP17 INHIBITORS
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Page/Page column 42, (2010/05/13)
Provided herein are inhibitors of CYP17 enzyme. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat androgen-dependent diseases, disorders and conditions.