68577-11-7Relevant academic research and scientific papers
Chemistry and Pharmacology of the Non-Benzodiazepine Anxiolytic Enciprazine and Related Compounds
Engel, Juergen,Fleischhauer, Ilona,Jakovlev, Vladimir,Kleemann, Axel,Kutscher, Bernhard,et al.
, p. 2976 - 2981 (2007/10/02)
In the course of studies on tranquilizers, new non-benzodiazepine-like compounds were synthesized.These are 1-(3,4,5-trimethoxyphenoxy)-3-propan-2-ol (INN: enciprazine) and derivatives thereof which were screened pharmacologically in order to evaluate their central nervous system activity.Compounds with marked antiaggressive and anxiolytic properties but without dependence potential could be detected.Enciprazine was selected for clinical investigations.
1-[3-(3,4,5-Trimethoxyphenoxy)-2-hydroxy-propyl]-4-aryl-piperazine-derivatives having pharmaceutical activity
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, (2008/06/13)
There are prepared compounds corresponding to the general formula STR1 in which R1 is a hydrogen atom, a C2 to C6 -alkanoyl group, a C3 to C6 -alkenoyl group, a C3 to C6 -cycloalkyl carbonyl group, a benzoyl group, an alkoxybenzoyl group, a nicotinoyl group, a thienyl carbonyl group, a furyl carbonyl group, a phenylacetyl group or a C1 to C4 -alkoxyphenyl acetyl group and R2 represents a phenyl, naphthyl or pyridyl group or such group substituted by the groups R3 and R4, the groups R3 and R4, which may be the same or different, each representing hydrogen, hydroxyl, fluorine, chlorine, bromine, a nitro group, a trifluoromethyl group, a C1 to C6 -alkyl group, a C1 to C6 -alkoxy group, a C1 to C6 -alkyl thio group, a C1 to C6 -alkyl sulphonyl group, a C2 to C6 -alkanoyl group, an amino group, an acylamino group or an acyloxy group in which the acyl is of the type defined in respect to R1, and their salts. The compounds are pharmacodynamically active.
