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Cyclo-(Leu-His), also known as cyclo-(leucyl-histidyl), is a cyclic dipeptide consisting of two amino acids, leucine and histidine, linked together in a cyclic structure. cyclo-(Leu-His) is formed through a dehydration reaction between the carboxyl group of leucine and the amino group of histidine, resulting in the formation of a peptide bond and the release of a water molecule. Cyclo-(Leu-His) has potential applications in pharmaceuticals, as it may exhibit biological activity or serve as a building block for the synthesis of more complex peptide-based drugs. Its unique cyclic structure also makes it an interesting subject for chemical and structural studies, as it can provide insights into the folding and stability of peptide chains.

6858-60-2

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6858-60-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6858-60-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,8,5 and 8 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 6858-60:
(6*6)+(5*8)+(4*5)+(3*8)+(2*6)+(1*0)=132
132 % 10 = 2
So 6858-60-2 is a valid CAS Registry Number.

6858-60-2Downstream Products

6858-60-2Relevant academic research and scientific papers

Cyclic dipeptides exhibit potency for scavenging radicals

Furukawa, Tadashi,Akutagawa, Takashi,Funatani, Hitomi,Uchida, Toshikazu,Hotta, Yoshihiro,Niwa, Masatake,Takaya, Yoshiaki

, p. 2002 - 2009 (2012/05/04)

Twenty kinds of cyclic dipeptides containing l-leucine were synthesized, and their antioxidant activity against .OH and O2·- was investigated. Compounds possessing polar amino acid residues, such as Asp, Cys, Glu, Lys, Pro, Ser, and Trp, exhibited higher antioxidant activity against .OH than vitamin E. However, only cyclo(l-Cys-l-Leu) scavenged O2·-.

Cyclo-((S)-leucyl-(S)-histidyl). A Catalyst for Asymmetric Addition of Hydrogen Cyanide to Aldehydes

Mori, Atsunori,Ikeda, Yoshitaka,Kinoshita, Koichi,Inoue, Shohei

, p. 2119 - 2122 (2007/10/02)

Asymmetric addition of hydrogen cyanide to various aldehydes in the presence of a catalytic amount of cyclo-((S)-leucyl-(S)-histidyl) affords the corresponding cyanohydrins in moderate to good optical yields.The reaction of benzaldehyde with hydrogen cyanide gives (S)-2-hydroxy-2-phenylacetonitrile (85percent, 55percent ee) whose stereochemistry is found to be opposite to our previous result using cyclo-((S)-phenylalanyl-(S)-histidyl).

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