79950-65-5

Basic information

• Product Name: N-Boc-N'-benzyloxymethyl-L-histidine
• Synonyms: nα-boc-π-bom-l-histidine;N-ALPHA-T-BUTYKOXYCARBONYL-N-IM-BENZYLOXYMETHYL-L-HISTIDINE;Nα-Boc-N(im)-benzyloxymethyl-L-histidine;NALPHA-tert-Butoxycarbonyl-N-imidazole-(benzyloxymethyl)-L-histidine;N-(tert-Butoxy)carbonyl-N'-benzyloxymethyl-L-histidine;N-Boc-N'-benzyloxymethyl-L-histidine;N-tert-Butoxycarbonyl-N(im)-benzyloxymethyl-L-histidine;Nα-Boc-π:-Bom-L-histidine, Nα-Boc-N(im)-benzyloxymethyl-L-histidine
• CAS NO: 79950-65-5
• Molecular Formula: C₁₉H₂₅N₃O₅
• Molecular Weight: 375.42
• Product Categories: Histidine [His, H];Boc-Amino Acids and Derivative;Boc-Amino acid series
• Mol File: 79950-65-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 122-125 °C
• Boiling Point: 595.3oC at 760 mmHg
• Flash Point: 313.8oC
• Appearance: White/Powder
• Density: 1.21g/cm3
• Vapor Pressure: 5.11E-15mmHg at 25°C
• Refractive Index: 1.562
• Storage Temp.: 2-8°C
• PKA: 3.55±0.10(Predicted)
• CAS DataBase Reference: N-Boc-N'-benzyloxymethyl-L-histidine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-N'-benzyloxymethyl-L-histidine(79950-65-5)
• EPA Substance Registry System: N-Boc-N'-benzyloxymethyl-L-histidine(79950-65-5)

Safety Data

• WGK Germany: 3
• F: 8
• Hazardous Substances Data: 79950-65-5(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

Boc-L-His(Bom)-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

InChI:InChI=1/C19H25N3O5/c1-19(2,3)27-18(25)21-16(17(23)24)9-15-10-20-12-22(15)13-26-11-14-7-5-4-6-8-14/h4-8,10,12,16H,9,11,13H2,1-3H3,(H,21,25)(H,23,24)/t16-/m0/s1

Upstream product

• 20898-43-5 4-(2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-1H-imidazole-1-carboxylic acid tert-butyl ester 
• 4467-54-3 l-histidine methyl ester dihydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 83468-80-8 N(α)-t-butoxycarbonyl-N(?)-benzyloxymethyl-L-histidine methyl ester hydrochloride 
• 79950-77-9 N^α-tert-Boc-N^?-<(benzyloxy)methyl>-L-histidine methyl ester 

Downstream Products

• 120742-07-6 5-<1-Hydroxy-2(S)-<(tert-butyloxycarbonyl)amino>-3-<3-(benzyloxymethyl)imidazol-4-yl>propylidene>-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 94818-43-6 Nα-Boc-N?-BOM-L-His-L-Leu methyl ester 
• 1381947-07-4 cyclo(N?-BOM-L-His-L-Leu) 
• 6858-60-2 cyclo-(Leu-His) 
• 79950-73-5 (S)-2-[(S)-3-(3-Benzyloxymethyl-3H-imidazol-4-yl)-2-(2-tert-butoxycarbonylamino-acetylamino)-propionylamino]-3-phenyl-propionic acid 
• 79950-68-8 (S)-2-[(S)-2-(2-tert-Butoxycarbonylamino-acetylamino)-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionic acid 
• 79950-75-7 (S)-2-[(S)-2-Amino-3-(3-benzyloxymethyl-3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionic acid methyl ester 
• 120742-10-1 N-Isovaleryl-L-Valyl-L-Valyl-4(S)-amino-5-<3-(benzyloxymethyl)imidazol-4-yl>-3(S)-hydroxypentanoic Acid Methyl Ester 
• 120849-35-6 (3S,4R)-5-(3-Benzyloxymethyl-3H-imidazol-4-yl)-3-hydroxy-4-{(S)-3-methyl-2-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-butyrylamino}-pentanoic acid methyl ester 
• 120742-09-8 (4S,5S)-1-(tert-Butyloxycarbonyl)-4-hydroxy-5-<<3-(benzyloxymethyl)imidazol-4-yl>methyl>pyrrolidin-2-one 
• 120742-08-7 (S)-2-(3-Benzyloxymethyl-3H-imidazol-4-ylmethyl)-3-hydroxy-5-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester 
• 83468-96-6 N(α)-t-butoxycarbonyl-N(?)-benzyloxymethyl-L-histidyl-N(?)-benzyloxymethyl-L-histidine methyl ester 

Relevant articles and documents

1,2-hydroxy phosphonates and derivatives thereof

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N-morpholino derivatives and their use as anti-hypertensive agents

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Protection of Histidine Side-chains with ?-Benzyloxymethyl- or ?-Bromobenzyloxymethyl-groups

N(α)-t-Butoxycarbonyl-N(?)-benzyloxymethyl-L-histidine (1) and N(α)-t-butoxycarbonyl-N(?)-4-bromobenzyloxymethyl-L-histidine (2) have been prepared and shown to be suitable derivatives for peptide synthesis with histidine; the synthetic intermediates had