68600-06-6

Upstream product

• 106754-81-8 4-fluoro-2-(4-isopropylphenylthio)phenylacetonitrile 
• 4946-14-9 4-mercapto-cumene 
• 61150-59-2 2-(2-bromo-4-fluorophenyl)acetic acid 
• 12775-96-1 copper 
• 106774-70-3 4-fluoro-2-(4-isopropylphenylthio)benzyl alcohol 
• 88848-16-2 4-fluoro-2-(4-isopropylphenylthio)benzyl chloride 
• 84589-14-0 4-fluoro-2-(4-isopropylphenylthio)benzoic acid 
• 56096-89-0 4-fluoro-2-iodobenzoic acid 
• 70931-61-2 (4-fluoro-2-iodophenyl)acetic acid 

Relevant academic research and scientific papers

ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE

Compounds of formula (I) and pharmaceutically acceptable salt thereof, which are modulators of secreted frizzled related protein-1, are disclosed. The compounds, and compositions containing the compounds, can be used to treat various diseases and disorders, including osteoporosis, arthritis, chronic obstructive pulmonary disease, cartilage defects, bone fractures, leiomyoma, acute myeloid leukemia, wound healing, prostate cancer, autoimmune inflammatory disorders, such as Graves ophthalmopathy, and combinations thereof.

FLUORINATED TRICYCLIC NEUROLEPTICS WITH PROLONGED ACTION: 7-FLUORO-11--2-ISOPROPYL-10,11-DIHYDRODIBENZOTHIEPIN

Substitution reaction of 11-chloro-7-fluoro-2-isopropyl-10,11-dihydrodibenzothiepin with 1-(2-hydroxyethyl)piperazine gave the title compound I which proved a very potent and long acting oral neuroleptic agent ("isofloxythepin").Its resolution by means of dibenzoyl-(+)- and (-)-tartaric acid led to (-)- and (+)-enantiomer out of which the former represents the neuroleptically active component.In the synthetic sequence leading to I, preparation of two key intermediates was re-elaborated using new partial sequences: 4-fluoro-2-iodobenzoic acid (XIII) from 4-fluoro-2-nitroaniline (V) via the nitrile VI and the acids VIII and XII, and acetic acid (XVIII) from XIII via XIV and the compounds XV-XVII.The sulfoxides and N-oxides XIX-XXII were prepared as potential metabolites of isofloxithepin (I).

3 Fluoro-10-piperazino-8-substituted 10,11-dihydrodibenzo-(bf) thiepins and method for the preparation thereof

Techniques for the preparation of 3-fluoro-10-piperazino-8-substituted 10,11-dihydrodibenzo-(b,f) thiepins and their addition salts with organic and inorganic acids are disclosed. The described compositions evidence psychotropic activity and low toxicity and are characterized as neuroliptics with a high degree of cataleptic, anti-apomorphine and central depressant action.