68617-64-1

Usage

Uses

Used in Bioconjugation:
3-(2-Pyridyldithio)propanoic Acid is used as a crosslinking agent for the immobilization of thrombogenesis-inhibiting enzymes on polymeric carriers. This allows for the development of biocompatible materials with enhanced bioactivity and stability.
Used in Drug Delivery:
3-(2-Pyridyldithio)propanoic Acid is used as a crosslinking agent in the targeted delivery of a triplex-forming oligonucleotide to hepatic stellate cells. This is achieved through the formation of complexes with phosphated bovine serum albumin, which aids in the treatment of liver fibrosis.
Used in Bioconjugation Industry:
3-(2-Pyridyldithio)propanoic Acid is used as a crosslinking agent for the immobilization of thrombogenesis-inhibiting enzymes on polymeric carriers. This application is crucial in the development of biocompatible materials with enhanced bioactivity and stability.
Used in Pharmaceutical Industry:
3-(2-Pyridyldithio)propanoic Acid is used as a crosslinking agent in the targeted delivery of a triplex-forming oligonucleotide to hepatic stellate cells. This application is significant in the treatment of liver fibrosis, as it allows for the development of more effective drug delivery systems.

Upstream product

• 2127-03-9 2,2'-dipyridyldisulphide 
• 107-96-0 3-mercaptopropionic acid 

Downstream Products

• 68181-17-9 N-succinimydyl 3-(2-pyridyldithio)propionate 
• 485800-27-9 3-((2-(tert-butoxycarbonylamino)ethyl)disulfanyl)propanoic acid 
• 1151989-27-3 3-((E)-3-hydroxyprop-1-enyl)-2-nitrobenzyl 3-(pyridin-2-yldisulfanyl)-propionate 
• 651355-01-0 C₁₃₂H₂₂₀N₃₂O₄₃S₂ 
• 115616-51-8 3-(2-pyridinyldithio)propanoic acid hydrazide 
• 870487-51-7 C₁₀H₁₃NO₂S₂ 

Relevant academic research and scientific papers

Exofacial protein thiols as a route for the internalization of Gd(III)-based complexes for magnetic resonance imaging cell labeling

Four novel MRI Gd(III)-based probes have been synthesized and evaluated for their labeling properties on cultured cell lines K562, C6, and B16. The labeling strategy relies upon the fact that cells display a large number of reactive exofacial protein thio

Macroporous p-type silicon Fabry-Perot layers. Fabrication, characterization, and applications in biosensing

We present in this paper that porous silicon can be used as a large surface area matrix as well as the transducer of biomolecular interactions. We report the fabrication of heavily doped p-type porous silicon with pore diameters that can be tuned, depending on the etching condition, from approximately 5 to 1200 nm. The structure and porosity of the matrixes were characterized by scanning force microscopy (SFM) and scanning electron microscopy (SEM), Brunnauer-Emmett-Teller nitrogen adsorption isotherms, and reflectance interference spectroscopy. The thin porous silicon layers are transparent to the visible region of the reflectance spectra due to their high porosity (80-90%) and are smooth enough to produce Fabry-Perot fringe patterns upon white light illumination. Porous silicon matrixes were modified by ozone oxidation, functionalized in the presence of (2- pyridyldithiopropionamidobutyl)dimethylmethoxysilane, reduced to unmask the sulfhydryl functionalities, and coupled to biotin through a disulfide-bond- forming reaction. Such functionalized matrixes display considerable stability against oxidation and corrosion in aqueous media and were used to evaluate the utility of porous silicon in biosensing. The streptavidin-biotin interactions on the surface of porous silicon could be monitored by the changes in the effective optical thickness calculated from the observed shifts in the Fabry-Perot fringe pattern caused by the change in the refractive index of the medium upon protein-ligand binding. Porous silicon thus combines the properties of a mechanically and chemically stable high surface area matrix with the function of an optical transducer and as such may find utility in the fabrication of biosensor devices.