686255-96-9Relevant academic research and scientific papers
Application of a unique automated synthesis system for solution-phase peptide synthesis
Sugawara,Kobayashi,Okamoto,Kitada,Fujino
, p. 1272 - 1280 (2007/10/02)
An automated synthesis system, which is suitable for repetitive syntheses using similar reaction procedures, was used to synthesize systematically a library of all possible dipeptides (25) and tripeptides (125) from 5 protected amino acids. The apparatus has also been applied to the automated synthesis of 10 fragment tripeptide derivatives that are constituents of the hormone PACAP-27. The measured molecular optical rotation values of the library of 125 tripeptides were found to correlate well with calculated values obtained by summation of the molecular optical rotation values for the constituent amino acids.
SYNTHESIS OF AN INSULIN-LIKE COMPOUND CONSISTING OF THE B CHAIN OF INSULIN AND AN A CHAIN CORRESPONDING TO THE A AND D DOMAINS OF HUMAN INSULIN-LIKE GROWTH FACTOR I
Schwartz, Gerald P.,Burke, G. Thompson,Sheikh, Maqsood,Zong, Lin,Katsoyannis, Panayotis G.
, p. 2920 - 2935 (2007/10/02)
We report the synthesis and biological evaluation of a two-chain, disulfide linked, insulin-like compound in which the A chain amino acid sequence correspond to that of the A- and D-domains of human insulin-like growth factor I (IGF-I), and the B chain is
