686263-53-6

Basic information

• Product Name: 1-benzyl-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-1,8-naphthyridin-2(1H)-one
• Synonyms: 1-benzyl-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-1,8-naphthyridin-2(1H)-one
• CAS NO: 686263-53-6
• Molecular Weight: 432.459
• Mol File: 686263-53-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-benzyl-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-1,8-naphthyridin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-1,8-naphthyridin-2(1H)-one(686263-53-6)
• EPA Substance Registry System: 1-benzyl-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-1,8-naphthyridin-2(1H)-one(686263-53-6)

Safety Data

• Hazardous Substances Data: 686263-53-6(Hazardous Substances Data)

Upstream product

• 97484-73-6 N-benzyl-2H-pyrido<2,3-d><1.3>oxazine-2,4 1H-dione 
• 145255-82-9 N-butyl-3-azaisatoic anhydride 
• 179064-00-7 1-benzyl-4-hydroxy-2-oxo-1,2-dihydro[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 3306-62-5 2-AMINOBENZENESULFONAMIDE 
• 50881-48-6 N-chlorosulfonyl-N'-phenyl-urea 
• 13338-00-6 2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide 
• 850814-27-6 1-benzyl-4-hydroxy-2-oxo-1,2-dihydro-[1,8]naphthyridine-3-carboxylic acid (2-sulfamoyl-phenyl)-amide 
• 53971-22-5 (1,1-dioxo-1,4-dihydro-1λ⁶-benzo-[1,2,4]-thiadiazin-3-yl)acetic acid ethyl ester 
• 222420-33-9 ethyl ester 2-aminosulfonylanilide of 2-sulfonylmalonic acid 
• 62-53-3 aniline 

Downstream Products

• 686267-63-0 1-benzyl-4-chloro-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-1,8-naphthyridin-2(1H)-one 

Relevant articles and documents

Inhibitors of HCV NS5B polymerase: Synthesis and structure-activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring

A series of non-nucleoside HCV NS5B polymerase inhibitors based on the N-1-benzyl or N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine core substituted in the D-ring aromatic moiety have been prepared and evaluated. Aromatic substituents extending from position 7 of the D-ring exhibited excellent potency against both genotypes 1a and 1b.

Anti-infective agents

Compounds having the formula are hepatitis C(HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C(HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.

Anti-infective agents

The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HC