68628-85-3

Upstream product

• 100-44-7 benzyl chloride 
• 73853-56-2 N-((2S,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-ylmethyl)-acetamide 
• 137272-88-9 1-acetamido-2,5-anhydro-3,4,6-tri-O-benzoyl-1-deoxy-D-allitol 
• 137272-74-3 1-amino-2,5-anhydro-3,4,6-tri-O-benzoyl-1-deoxy-D-allitol 
• 23316-67-8 2,3,5-tri-O-benzoyl-β-D-ribofuranosyl-1-carbonitrile 

Downstream Products

• 137272-89-0 methyl 3-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)-1H-pyrazole-5-carboxylate 
• 137305-06-7 3-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)-1H-pyrazole-5-carboxamide 
• 52492-49-6 2,5-anhydro-3,4,6-tri-O-benzyl-1-deoxy-1-(N-nitrosoacetamido)-D-allitol 

Relevant academic research and scientific papers

CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS

The present invention is directed to compounds of the formula (I) wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS

The present invention is directed to compounds of the formula (I), wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

A convenient synthesis of 4-deoxypyrazofurin

A preparation of 3-β-D-ribofuranosyl-1H-pyrazole-5-carboxamide (4-deoxypyrazofurin, 3) is reported in nine steps (in an overall yield of 21%) beginning with 2,5-anhydro-3,4,6-tri-O-benzoyl-D-allonitrile (6) and proceeding via a 1,3-dipolar cycloaddition reaction between methyl propiolate and 2,5-anhydro-3,4,6-tri-O-benzyl-1-deoxy-1-diazo-D-allitol (4).