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Usage

Uses

Used in Pharmaceutical Industry:
3-Amino-6-bromo-1H-pyrazine-2-thione is used as a key intermediate in the synthesis of various pharmaceuticals for its versatile reactivity and biological activity. It contributes to the development of new drugs with potential therapeutic benefits.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Amino-6-bromo-1H-pyrazine-2-thione serves as a crucial building block in the creation of agrochemicals, such as pesticides and herbicides, due to its ability to enhance the effectiveness of these compounds.
Used in Heterocyclic Compounds Synthesis:
3-Amino-6-bromo-1H-pyrazine-2-thione is utilized as a valuable precursor in the preparation of heterocyclic compounds, which are essential in various chemical and pharmaceutical applications.
Used in Antimicrobial Applications:
Research has shown that 3-Amino-6-bromo-1H-pyrazine-2-thione possesses antimicrobial properties, making it a potential candidate for the development of new antimicrobial agents to combat resistant bacterial strains.
Used in Antiviral Applications:
3-AMINO-6-BROMO-1H-PYRAZINE-2-THIONE has also been investigated for its antiviral properties, indicating its potential use in the development of novel antiviral therapeutics to address emerging viral diseases and infections.

Upstream product

• 24241-18-7 2-amino-3,5-dibromopyrazine 

Downstream Products

• 87444-41-5 6-bromo-2-methylthiazolo<4,5-b>pyrazine 
• 87444-40-4 6-bromothiazolo<4,5-b>pyrazine 
• 93497-79-1 6-bromo-2-phenylthiazolo<4,5-b>pyrazine 
• 87444-42-6 6-bromo-2-ethoxy-2-methyl-2,3-dihydrothiazolo<4,5-b>pyrazine 
• 87444-38-0 5-bromo-3-(methylthio)pyrazin-2-amine 

Relevant academic research and scientific papers

Synthesis of tetraaza derivatives of benzoxazinophenothiazine

Tetraaza benzoxazinophenothiazine heterocyclic rings were synthesized and characterized. The key intermediate, 11-amino-6-chlorobenzo[a]-8,10-diazaphenoxazin-5-one was prepared by reaction of 4,5-diamino-6-hydroxypyimidine with 2,3-dichloro-1,4-naphthoquinone in anhydrous sodium carbonate. Whereas the parent tetraaza derivatives: 15-amino-8-bromo-6,9,12,14-tetraazabenzo[a][1,4]benzoxazino[3,2-c] phenothiazine, 9,15-diamino-6,8,12,14-tetraazabenzo[a][1,4]benzoxazino[3,2-c]pheno- thiazine and 15-amino-6,8,12,14-tetraazabenzo[a][1,4]benzoxazino[3,2-c]phenothiazine were synthesized by base catalyzed condensation reactions of 11-amino-6-chlorobenzo[a]-8,10-diazaphenoxazin-5-one with 2-amino-5-bromopyrazin-3-thiol, 4,6-diaminopyrimidine-5-thiol and 4-diaminopyrimidine-5-thiol respectively. The compounds are intensely coloured and are readily reduced with sodium dithionite to their leuco bases which can make them applicable as vat dyes. Their wash fastness, sublimation fastness and staining undyed fabric were evaluated.

Palladium catalyzed transformation and antimicrobial screening of novel angular azaphenothiazines

Base mediated condensation reaction between 2-amino-5-bromopyrazine-3[4H]-thione and 7-chloro-5,8-quinolinequinone under anhydrous condition gave 9-bromo-1,8,11-triaza-5H-benzo[a]phenothiazin-5-one. Palladium catalyzed cross-coupling reaction between 9-bromo-1,8,11-triaza-5H-benzo[a]phenothiazin-5-one and four arylated halogeno compounds utilizing Heck-Mizoroki protocol furnished 6-substituted derivatives of the angular tetracyclic heterocycle. Structures were assigned based on spectroscopic and elemental analytical data. Antimicrobial screening of these compounds showed they were biologically active.

USE OF CONDENSED BENZO[B]THIAZINE DERIVATIVES AS CYTOPROTECTANTS

The present invention relates to arylthiazine compounds, metabolites, N-oxides, amides, esters,pharmaceutically acceptable salts, hydrates and solvates thereof and their use as cytoprotectants in the treatment or prophylaxis of diseases or states, either acute or chronic, involving aberrant cellular lipid peroxidation in the central nervous system or in the periphery of the body. The present invention also relates to a method for their preparation and to pharmaceutical composition comprising as an active ingredient one or more of the aforementioned compounds.