68634-48-0

Basic information

• Product Name: 3-(2-oxopyridin-1(2H)-yl)propanoic acid
• Synonyms: 1(2H)-Pyridinepropanoic acid, 2-oxo;3-(2-oxo-1(2H)-pyridinyl)propanoic acid(SALTDATA: FREE);3-(2-keto-1-pyridyl)propionic acid;3-(2-oxo-1-pyridyl)propanoic acid;3-(2-Oxo-2H-pyridin-1-yl)-propionic acid;3-(2-oxopyridin-1-yl)propanoic acid;MFCD07391228;3-(2-oxopyridin-1(2H)-yl)propanoic acid
• CAS NO: 68634-48-0
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.16
• Mol File: 68634-48-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 441.5 °C at 760 mmHg
• Flash Point: 220.8 °C
• Appearance: /
• Density: 1.292g/cm³
• Vapor Pressure: 5.01E-09mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(2-oxopyridin-1(2H)-yl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-oxopyridin-1(2H)-yl)propanoic acid(68634-48-0)
• EPA Substance Registry System: 3-(2-oxopyridin-1(2H)-yl)propanoic acid(68634-48-0)

Safety Data

• Hazardous Substances Data: 68634-48-0(Hazardous Substances Data)

Usage

General Description

3-(2-oxopyridin-1(2H)-yl)propanoic acid is a chemical compound with the molecular formula C8H9NO3. This substance is a member of the class of compounds known as carboxylic acids and derivatives, in which the carbon of a carbonyl group is bonded to two additional carbon atoms. It specifically falls under the subclass of pyridinecarboxylic acids and derivatives. These are compounds containing a pyridine ring bearing a carboxylic acid or a derivative thereof. It has a role as a human xenobiotic metabolite. However, its specific application in science and industry is not widely documented in the literature.

InChI:InChI=1/C8H9NO3/c10-7-3-1-2-5-9(7)6-4-8(11)12/h1-3,5H,4,6H2,(H,11,12)

Upstream product

• 25386-51-0 3-(2-oxo-2H-pyridin-1-yl)-propionitrile 
• 107-94-8 chloropropionic acid 
• 142-08-5 2-Pyridone 
• 68634-47-9 methyl 3-[2-oxopyridin-1(2H)-yl]propanoate 
• 141-76-4 3-iodopropanoic acid 

Downstream Products

• 142-08-5 2-Pyridone 
• 79-10-7 acrylic acid 
• 117705-04-1 3-(2-oxopiperidin-1-yl)propionic acid 

Relevant articles and documents

Development of novel amides as noncovalent inhibitors of immunoproteasomes

The development of immunoproteasome-selective inhibitors is a promising strategy for treating hematologic malignancies, autoimmune and inflammatory diseases. In this context, we report the design, synthesis, and biological evaluation of a new series of amide derivatives as immunoproteasome inhibitors. Notably, the designed compounds act as noncovalent inhibitors, which might be a promising therapeutic option because of the lack of drawbacks and side effects associated with irreversible inhibition. Among the synthesized compounds, we identified a panel of active inhibitors with Ki values in the low micromolar or sub-micromolar ranges toward the b5i and/or b1i subunits of immunoproteasomes. One of the active compounds was shown to be the most potent and selective inhibi-tor with a Ki value of 21 nm against the single b1i subunit. Docking studies allowed us to determine the mode of binding of the molecules in the catalytic site of immunoproteasome subunits.

Reactions Using Micellar Systems. IV. Regioselectivity in the Photodimerizations of 2-Pyridones in Micelles and Reversed Micelles

Photodimerizations of N-alkyl-2-pyridones (1a-e), N-ω-carboxyalkyl-2-pyridones (1f-h),and N-2'-carboxyethyl-4-alkyl-2-pyridones (1i and 1j) in micellar and reversed micellar systems gave the following results; 1) in the reactions of 1a-e, the cis/trans ratios of dimers increased with decreasing concentration of the probes, with the octyl compound (1d) showing the highest selectivity; 2) in the case of 1f-h, the ratios increased up to 1.0 with decreasing alkyl chain length; 3) below 7.2 mM concentration, 1i gave exclusively the cis dimer, while only the trans dimer was formed when the reaction was carried out in water.The results indicate that the regio-control of the reactions was a result of the alignment effect of micelles on the substrate, and moreover, in both micellar systems, not only the distribution of amphiphilic probes between micellar and bulk (water or cyclohexane) phases but also the orientation and incorporation site of the pyridone moiety play important roles in the regioselectively for the cis dimer.Keywords - N-alkyl-2-pyridone; N-ω-carboxyalkyl-2-pyridone; N-2'-carboxyethyl-4-alkyl-2-pyridone; micelle; reversed micelle; dimer; photodimerization; regioselectivity; alignment effect; amphiphile