686344-48-9Relevant articles and documents
Development of a Practical and Efficient Synthesis of CP-945, 598-01, a CBi Antagonist for the Treatment of Obesity
Ragan, John A.,Bourassa, Dennis E.,Blunt, Jon,Breen, Darragh,Busch, Frank R.,Cordi, Eric M.,Damon, David B.,Do, Nga,Engtrakul, Alanya,Lynch, Denis,McDermott, Ruth E.,Mongillo, Joseph A.,O'Sullivan, Maria M.,Vanderplas, Peter R. RoseBrian C.
experimental part, p. 186 - 197 (2010/04/22)
Development of an efficient bond-forming sequence and optimization of reaction conditions are described for the synthesis of CP-945, 598-01 (1-HC1), a CB, antagonist in clinical studies for the treatment of obesity. Reordering of the bond-forming sequence
New bicyclic cannabinoid receptor-1 (CB1-R) antagonists
Carpino, Philip A.,Griffith, David A.,Sakya, Subas,Dow, Robert L.,Black, Shawn C.,Hadcock, John R.,Iredale, Philip A.,Scott, Dennis O.,Fichtner, Michael W.,Rose, Colin R.,Day, Robert,Dibrino, Joseph,Butler, Mary,DeBartolo, Demetria B.,Dutcher, Darrin,Gautreau, Denise,Lizano, Jeff S.,O'Connor, Rebecca E.,Sands, Michelle A.,Kelly-Sullivan, Dawn,Ward, Karen M.
, p. 731 - 736 (2007/10/03)
A series of conformationally constrained bicyclic derivatives derived from SR141716 was prepared and evaluated as hCB1-R antagonists and inverse agonists. Optimization of the structure-activity relationships around the 2,6-dihydro-pyrazolo[4,3-
BICYCLIC IMIDAZOLYL PYRIMIDIN-4-ONE CANNABINOID RECEPTOR LIGANDS AND USES THEREOF
-
Page/Page column 46-47, (2010/02/12)
Compounds of Formula (I) are described herein. The compounds have been shown to act as cannabinoid receptor ligands and are therefore useful in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals.
