68675-27-4

Usage

Uses

Used in Pharmaceutical Industry:
(E)-N'-(6-chloropyridazin-3-yl)-N,N-diMethylacetaMidine is used as a potential antihypertensive agent for the treatment of hypertension. It has been studied for its ability to modify the activity of certain receptors in the central nervous system, which could have implications for the treatment of various neurological disorders.
Used in Medicinal Chemistry Research:
(E)-N'-(6-chloropyridazin-3-yl)-N,N-diMethylacetaMidine is used as a valuable tool for researchers in the field of medicinal chemistry. Its unique chemical structure and properties make it useful for studying the mechanisms of hypertension and other related conditions, as well as for developing new treatments and therapies.

Upstream product

• 5469-69-2 6-chloro-pyridazin-3-ylamine 
• 18871-66-4 N,N-dimethylacetamide dimethyl acetal 

Downstream Products

• 90734-74-0 (6-Chloro-2-methyl-imidazo[1,2-b]pyridazin-3-yl)-phenyl-methanone 
• 90734-73-9 1-(6-chloro-2-methylimidazole[1,2-b]pyridazine-3-yl)ethanone 
• 55643-82-8 6-Chloro-2-methyl-s-triazolo<1,5-b>pyridazine 

Relevant academic research and scientific papers

COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY

The present invention provides compounds of formula (I) wherein A, X, Y, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.

IMIDAZOPYRIDAZINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY

A series of substituted imidazo[1,2-b]pyridazine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory dis

Reactions of N-Heteroarylformamide Oximes and N-Heteroarylacetamide Oximes with N,N-Dimethylformamide Dimethyl Acetal. Synthesis of 2-Methyl-s-triazoloazines and N-Methylcyanoaminoazines

N-Heteroarylformamide oximes 3 (R = H) were converted with N,N-dimethylformamide dimethyl acetal (DMFDMA) into N-heteroaryl-N-methylcyanoamino compounds 5, as the main products.In some instances N-heteroarylcyanoamino compounds 4, cyanoimino compounds 7, and some other products, such as 9 and 10 were also formed.On the other hand, N-heteroarylacetamide oximes 3 (R = CH3) were cyclized under the same reaction conditions into 2-methyl-s-triazoloazines (6).N-Heteroarylacetamide O-methyl oximes 11 and 12 were prepared from the corresponding acetamidines 2 (R = CH3) and O-methylhydroxylamine.