68676-88-0

Basic information

• Product Name: Trichostatin C
• Synonyms: 7-[4-(Dimethylamino)phenyl]-N-(β-D-glucopyranosyloxy)-4,6-dimethyl-7-oxo-2,4-heptadienamide;145-A
• CAS NO: 68676-88-0
• Molecular Formula: C23H32N2O8
• Molecular Weight: 464.512
• Mol File: 68676-88-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 171-173°
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.33g/cm³
• Refractive Index: 1.608
• PKA: 12.85±0.70(Predicted)
• CAS DataBase Reference: Trichostatin C(CAS DataBase Reference)
• NIST Chemistry Reference: Trichostatin C(68676-88-0)
• EPA Substance Registry System: Trichostatin C(68676-88-0)

Safety Data

• Hazardous Substances Data: 68676-88-0(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 68676-88-0 differently. You can refer to the following data:
1. Trichostatin C is the first example of a glucopyranosyl hydroxamate from nature. The conjugation may act to protect the less stable N-OH group of Trichostatin A. Trichostatin C displays antifungal, antiprotozoan and antitumour activity, albeit less potent than trichostatin A
2. Trichostatin C is an inducer of erythroid differentiation and histone H4 acetylation level.

InChI:InChI=1/C23H32N2O8/c1-13(11-14(2)19(28)15-6-8-16(9-7-15)25(3)4)5-10-18(27)24-33-23-22(31)21(30)20(29)17(12-26)32-23/h5-11,14,17,20-23,26,29-31H,12H2,1-4H3,(H,24,27)/b10-5+,13-11+/t14-,17-,20-,21+,22-,23+/m1/s1

Upstream product

• 833476-60-1 (3aR,7aS)-2-[(2R,3R,4S,5R,6R)-3,4,5-Tris-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-pyran-2-yloxy]-hexahydro-isoindole-1,3-dione 
• 833476-56-5 (3aR,7aS)-2-((2R,3R,4S,5R,6R)-3,4,5-Tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-hexahydro-isoindole-1,3-dione 
• 833476-62-3 O-[3,4,5-tris-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-pyran-2-yl]-hydroxylamine 
• 114127-17-2 (S)-trichostatic acid 
• 1122-91-4 4-bromo-benzaldehyde 
• 4291-69-4 2,3,4,6-Tetra-O-benzyl-D-glucopyranose 
• 58880-19-6 trichostatin A 
• 120221-14-9 (2-chloro-4-nitrophenyl)-β-D-glucopyranoside 
• 833476-46-3 (R)-3-[(E)-(4R,5R)-5-(4-Bromo-phenyl)-5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-pent-2-enoyl]-4-isopropyl-oxazolidin-2-one 
• 833476-42-9 (4R,1'E,3'E)-(-1'-{[tert-butyl(dimethyl)silyl]oxy}-2'-methyl-1',3'-pentadienyl)-4-isopropyl-1,3-oxazolidin-2-one 
• 833476-48-5 (E)-(4R,5R)-5-(4-Bromo-phenyl)-5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-pent-2-enal 
• 114127-18-3 (+)-(R)-trichostatin acid 
• 833476-58-7 (3aR,7aS)-2-((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-hexahydro-isoindole-1,3-dione 
• 794525-07-8 (4S,1'E,3'E)-(-1'-{[tert-butyl(dimethyl)silyl]oxy}-2'-methyl-1',3'-pentadienyl)-4-isopropyl-1,3-oxazolidin-2-one 

Relevant articles and documents

OleD Loki as a Catalyst for Tertiary Amine and Hydroxamate Glycosylation

We describe the ability of an engineered glycosyltransferase (OleD Loki) to catalyze the N-glycosylation of tertiary-amine-containing drugs and trichostatin hydroxamate glycosyl ester formation. As such, this study highlights the first bacterial model catalyst for tertiary-amine N-glycosylation and further expands the substrate scope and synthetic potential of engineered OleDs. In addition, this work could open the door to the discovery of similar capabilities among other permissive bacterial glycosyltransferases.