686775-60-0Relevant academic research and scientific papers
E/Z Isomerization of 3,3-disubstituted allylic thioethers
Havranek, Miroslav,Sauerberg, Per,Kratina, Pavel,Pihera, Pavel
, p. 6970 - 6973 (2008/02/13)
Allylic thioethers of the general structure 1 underwent E/Z isomerization during both basic and acidic hydrolysis of the ester moiety at the remote end of the molecule. The isomerization was dependent on the substitution of the allylic moiety. The presenc
Novel selective PPARδ agonists: Optimization of activity by modification of alkynylallylic moiety
Havranek, Miroslav,Sauerberg, Per,Mogensen, John P.,Kratina, Pavel,Jeppesen, Claus B.,Pettersson, Ingrid,Pihera, Pavel
, p. 4144 - 4149 (2008/03/11)
Y-shaped molecules bearing alkynylallylic moieties were found to be potent and selective PPARδ activators. The alkynylallylic moiety was synthesized from alkyn-1-ols by hydroalumination followed by a cross-coupling reaction. Series of active compounds 6 w
NOVEL COMPOUNDS, THEIR PREPARATION AND USE
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Page/Page column 48, (2010/02/14)
Novel compounds of the general formula (I), in which the variables are as defined in claim 1, the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compound
NOVEL COMPOUNDS USEFUL IN TREATING PPAR MEDIATED DISEASES
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Page 46, (2010/11/30)
Novel compounds of the general formula (I), the use of these compounds as pharma-ceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be
