68690-18-6Relevant academic research and scientific papers
SYNTHESIS OF HDAC INHIBITORS: TRICHOSTATIN A AND ANALOGUES
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Page/Page column 7, (2011/10/12)
Embodiments herein relate to histone deacetylaces (HDACs) and HDAC inhibitors, such as trichostatin A (TSA) and TSA analogues. Embodiments provide simple methods of synthesizing TSA and TSA analogues. These methods provide routes of synthesis of TSA and TSA analogues that enable the production of the HDAC inhibitors at lower cost and in greater quantities than previously were available.
Concise, convergent syntheses of (±)-trichostatin a utilizing a Pd-catalyzed ketone enolate α-alkenylation reaction
Cosner, Casey C.,Helquist, Paul
, p. 3564 - 3567 (2011/09/14)
Two concise, convergent syntheses of (±)-trichostatin A (1), a potent histone deacetylase inhibitor, have been accomplished. The key step in both is a Pd-catalyzed α-alkenylation reaction between ketone 2 and either dienyl bromide 3 or alkenyl bromide 9 u
