68691-66-7

Upstream product

• 68691-65-6 (3S,4S,5S,8R)-3,4-Dihydroxy-3-methyl-12-methylene-1,9-dioxa-6,13-diaza-dispiro[4.2.4.2]tetradecane-7,14-dione 
• 586-75-4 4-chlorobenzoyl chloride 
• 1053631-97-2 Methanesulfonic acid (1S,6R)-1-[(S)-hydroxy-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl]-5-methylene-8,10-dioxo-2-oxa-7,9-diaza-bicyclo[4.2.2]dec-6-yl ester 
• 205035-46-7 Thioacetic acid S-{(1S,6R)-1-[(S)-hydroxy-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl]-5-methylene-8,10-dioxo-2-oxa-7,9-diaza-bicyclo[4.2.2]dec-6-yl} ester 
• 205035-47-8 (1S,6R)-1-[(S)-Hydroxy-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl]-6-mercapto-5-methylene-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione 
• 205035-39-8 (1S,6S)-6-Amino-1-[(S)-hydroxy-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl]-5-methylene-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione 
• 205035-30-9 (1S,6S)-6-Amino-5-methylene-1-((1S,2S)-1,2,3-trihydroxy-2-methyl-propyl)-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione 
• 1053717-09-1 (1S,6R)-6-Mercapto-5-methylene-1-((1S,2S)-1,2,3-trihydroxy-2-methyl-propyl)-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione 
• 63777-16-2 dihydrobicyclomycin 2',3'-acetonide 
• 141509-42-4 4,4-dimethyl-3,5-dioxacycloheptanone 
• 3027-05-2 N,N'-diacetylpiperazin-2,5-dione 

Relevant academic research and scientific papers

Role of the C(6)-hydroxy group in bicyclomycin: Synthesis, structure, and chemical, biochemical, and biological properties

Bicyclomycin (1) is a commercial antibiotic whose primary site of action in Escherichia coli is the transcription termination factor rho. A recent structure-activity relationship study of 1 showed that replacing the C(6)- hydroxy group with alkoxy and thi