68692-38-6Relevant academic research and scientific papers
Novel analogues of degarelix incorporating hydroxy-, methoxy-, and pegylated-urea moieties at positions 3, 5, 6 and the N-terminus. Part III
Samant, Manoj P.,Hong, Doley J.,Croston, Glenn,Rivier, Catherine,Rivier, Jean
, p. 3536 - 3543 (2006)
Novel degarelix (Fe200486) analogues were screened for antagonism of GnRH-induced response (IC50) in a reporter gene assay. Inhibition of luteinizing hormone release over time was measured in the castrated male rat. Nω-Hydroxy- and N
Electrochemical access to benzimidazolone and quinazolinone derivatives: Via in situ generation of isocyanates
Saha, Debarshi,Taily, Irshad Maajid,Naik, Sumitra,Banerjee, Prabal
supporting information, p. 631 - 634 (2021/01/29)
Isocyanates are the key intermediates for several organic transformations towards the synthesis of diverse pharmaceutical targets. Herein, we report the development of an oxidant-free protocol for electrochemical in situ generation of isocyanates. This strategy highlights expedient access to benzimidazolones and quinazolinones and eliminates the need for exogenous oxidants. Furthermore, detailed mechanistic studies provide strong support towards our hypothesis of in situ isocyanate generation. This journal is
Synthesis of Cyclic N-Hydroxylated Ureas and Oxazolidinone Oximes Enabled by Chemoselective Iodine(III)-Mediated Radical or Cationic Cyclizations of Unsaturated N-Alkoxyureas
Peilleron, Laure,Retailleau, Pascal,Cariou, Kevin
supporting information, p. 5160 - 5169 (2019/11/11)
In this study we describe the reactivity of unsaturated N-alkoxyureas in the presence of different combinations of a hypervalent iodine(III) reagent and a bromide source or TEMPO. Three complementary cyclizations can be achieved depending on the reaction conditions. On the one hand, PIFA with pyridinium bromide leads to an oxybromination reaction. On the other hand, bis(tert-butylcarbonyloxy)iodobenzene with tetrabutylammonium bromide or TEMPO triggers aminobromination or aminooxyamination reactions, respectively. Control experiments showed that the three reactions proceed through distinct mechanisms: the first process is ionic while the other two follow a radical manifold. (Figure presented.).
Practical convergent laboratory-scale synthesis of a CCR5 receptor antagonist
Crawford, Jason B.,Chen, Gang,Carpenter, Bryon,Wilson, Trevor,Ji, Jenny,Skerlj, Renato T.,Bridger, Gary J.
experimental part, p. 109 - 116 (2012/05/31)
An efficient laboratory-scale synthesis has been developed for the selective CCR5 antagonist 1. The convergent route has a longest linear sequence of nine steps (15 steps overall), and has overall yields of 18-25%. The route has enabled the preparation of 550 g of 1.
