687-69-4

Basic information

• Product Name: H-ALA-GLY-OH
• Synonyms: ALA-GLY;L-ALANYLGLYCINE;H-ALA-GLY-OH;Glycine, N-L-alanyl-;L-alpha-Alanylglycine;N-L-Alanylglycine;L-ALANYL GLYCINE extrapure;L-Ala-Gly-OH
• CAS NO: 687-69-4
• Molecular Formula: C₅H₁₀N₂O₃
• Molecular Weight: 146.14
• EINECS: 211-699-9
• Product Categories: Amino Acid Derivatives
• Mol File: 687-69-4.mol
• Article Data: 14

Chemical Properties

• Melting Point: 249-255 °C (dec.)
• Boiling Point: 417.4 °C at 760 mmHg
• Flash Point: 206.2 °C
• Appearance: /
• Density: 1.263 g/cm³
• Storage Temp.: −20°C
• PKA: 3.14±0.10(Predicted)
• BRN: 1723438
• CAS DataBase Reference: H-ALA-GLY-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-ALA-GLY-OH(687-69-4)
• EPA Substance Registry System: H-ALA-GLY-OH(687-69-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 687-69-4(Hazardous Substances Data)

Usage

Uses

H-ALA-GLY-OH is an amino acid reagent used in the synthesis of ternary copper(II)?-?L-?dipeptide-?neocuproine complexes used in cancer treatment.

Definition

ChEBI: A dipeptide formed from L-alanyl and glycine residues.

InChI:InChI=1S/C5H10N2O3/c1-3(6)5(10)7-2-4(8)9/h3H,2,6H2,1H3,(H,7,10)(H,8,9)/t3-/m1/s1

Upstream product

• 56-40-6 glycine 
• 18409-49-9 N-carbamoyl-L-alanine 
• 19729-30-7 Gly-Gly-Ala 
• 2491-20-5 L-alanine methyl ester hydrochloride 
• 56-41-7 L-alanin 
• 25172-67-2 Z-Ala-O-COO-isoBu 
• 103-72-0 phenyl isothiocyanate 
• 121574-51-4 Ac-Ala-DAPA-Ala-Gly-OH 
• 4526-77-6 L-alanylglycine diketopiperazine 
• 91861-95-9 Ac-Ala-Gln-Ala-Gly-OH 
• 121574-50-3 Ac-Ala-DABA-Ala-Gly-OH 
• 66285-47-0 H-Ala-Gly-OBzl 
• 459-73-4 GlyOEt*HCl 
• 2224-52-4 L-alanine N-carboxyanhydride 

Downstream Products

• 56-41-7 L-alanin 
• 56-40-6 glycine 
• 1374765-48-6 (Nα-[(2-benzoylamino-adamantan-2-yl)carbonyl]-(S)-alanyl)-glycine 
• 96684-28-5 N-Boc-L-γ-glutamyl-L-alanylglycine α-benzyl ester 
• 16305-88-7 γ-L-Glu-L-Ala-Gly 
• 23404-09-3 (S)-1-((2-methoxy-2-oxoethyl)amino)-1-oxopropan-2-aminium chloride 
• 1188-01-8 dl-alanylglycine 
• 4526-77-6 L-alanylglycine diketopiperazine 
• 3997-90-8 D-ala-gly 
• 118507-30-5 [(S)-2-(4-Bromomethyl-benzoylamino)-propionylamino]-acetic acid 
• 33511-31-8 N-tert.-Butyloxycarbonyl-S-trityl-L-cysteinyl-S-diphenylmethyl-L-cysteinyl-alanyl-glycin 
• 95753-62-1 DL-5-methyl-3-<4-<(2S)-Fmocamino-2-methoxycarbonylethyl>phenyl>-2-thiohydantoin 
• 83014-06-6 C₉H₁₇N₂O₄ 
• 83058-92-8 C₉H₁₇N₃O₄^(1-) 

Relevant articles and documents

Analysis of vibrational spectra of l-alanylglycine based on density functional theory calculations

FT Raman and IR spectra of the crystallized biologically active molecule, l-alanylglycine (l-Ala-Gly) have been recorded and analyzed. The equilibrium geometry, bonding features and harmonic vibrational frequencies of L-Ala-Gly have been investigated with

Coupling-Reagent-Free Synthesis of Dipeptides and Tripeptides Using Amino Acid Ionic Liquids

A general method for the synthesis of dipeptides has been developed, which does not require any coupling reagents. This method is based on the reaction of readily available HCl salts of amino acid methyl esters with tetrabutylphosphonium amino acid ionic liquids. The isolation procedure of stepwise treatment with AcOH is easy to carry out. The method was extended to the synthesis of tripeptide, tyrosyl-glycyl-glycine, present in IMREG-1, also.

The peptide formation mediated by cyanate revisited. N-carboxyanhydrides as accessible intermediates in the decomposition of N-carbamoylamino acids

Similar to many ureas, N-carbamoylamino acids were shown to be hydrolyzed in aqueous solution through elimination mechanisms at close to neutral pH, the nucleophilic attack of water being a minor process. Two competing elimination mechanisms can take place involving either cyanate or isocyanate transient intermediates. Peptide formation was observed and attributed to the latter pathway through the intermediacy of amino acid N-carboxyanhydride (NCA). Eventually, cyanate and its precursors (including urea) unexpectedly behave as amino acid activating agents because of their ability in amino acid carbamoylation. Owing to its ability to generate a background prebiotic production of NCAs on the primitive Earth, this reaction is suggested to have contributed to the origin of life process. Copyright