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Retronecine N-oxide is a naturally occurring chemical compound found in plants of the Senecio genus, particularly in species known as ragwort. It is a toxic alkaloid, which means it has a bitter taste and can be harmful or fatal if ingested in large quantities. The compound is structurally similar to the amino acid leucine, which can lead to its incorporation into proteins during protein synthesis, potentially causing misfolding and disrupting normal cellular functions. This can result in various health issues, including liver damage and other toxic effects in animals that consume the plants containing retronecine N-oxide. The presence of Retronecine N-oxide in certain plants has led to concerns about its impact on livestock and wildlife that may ingest these plants, making it a subject of interest in the fields of toxicology and plant ecology.

6870-33-3

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6870-33-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6870-33-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,8,7 and 0 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 6870-33:
(6*6)+(5*8)+(4*7)+(3*0)+(2*3)+(1*3)=113
113 % 10 = 3
So 6870-33-3 is a valid CAS Registry Number.
InChI:InChI=1/2C8H13NO3/c2*10-5-6-1-3-9(12)4-2-7(11)8(6)9/h2*1,7-8,10-11H,2-5H2/t2*7-,8-,9+/m11/s1

6870-33-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (1R,4R,8R)-7-(hydroxymethyl)-4-oxido-2,3,5,8-tetrahydro-1H-pyrrolizin-4-ium-1-ol

1.2 Other means of identification

Product number -
Other names Isatinecine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6870-33-3 SDS

6870-33-3Downstream Products

6870-33-3Relevant academic research and scientific papers

Synthesis of pyrrolizidine alkaloids indicine, intermedine, lycopsamine, and analogues and their N-oxides. Potential antitumor agents

Zalkow,Glinski,Gelbaum,Fleischmann,McGowan,Gordon

, p. 687 - 694 (2007/10/02)

(-)- and (+)-trachelanthic and (-)- and (+)-viridifloric acids were synthesized and their isopropylidene derivatives were regiospecifically coupled, at C-9, with (-)-retronecine (2) obtained by hydrolysis of monocrotaline (1), isolated from Crotalaria spectabilis. Hydrolysis, followed by oxidation, led to the N-oxides of indicine (7), intermedine (13), lycopsamine (15), and the new nonnatural product 16, respectively. Each of these analogues was screened in the P388 lymphocytic leukemia system at the same time as indicine N-oxide, and the results were compared. Other related analogues were prepared and similarly screened and the results compared with those from indicine N-oxide.

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