68701-14-4Relevant articles and documents
Synthesis of Novel Imidazobenzodiazepines as Probes of the Pharmacophore for "Diazepam-Insensitive" GABAA Receptors
Zhang, Puwen,Zhang, Weijiang,Liu, Ruiyan,Harris, Bradford,Skolnick, Phil,Cook, James M.
, p. 1679 - 1688 (2007/10/02)
The syntheses of a series of novel imidazobenzodiazepines and their affinities for diazepam sensitive (DS) and diazepam insensitive (DI) GABAA receptors are described.Imidazobenzodiazepines belong to one of the very few chemical families which
2-OXY-4H-3,1-BENZOXAZIN-4-ONES AND PHARMACEUTICAL USE
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, (2008/06/13)
2-Oxy-4H-3,1-benzoxazin-4-ones represented by the formula: STR1 and the pharmaceutically acceptable acid addition salts thereof, wherein: a is an integer of 0-4;A is a bond, or alkylene having one to eight carbon atoms;R is hydrogen, phenyl, imidazolyl or cycloalkyl having three to six carbon atoms, wherein the phenyl, imidazolyl or cycloalkyl ring is optionally substituted with 1-3 substituents independently selected from the group consisting of lower alkyl having one to four carbon atoms, lower alkoxy having one to four carbon atoms,--N(R 1) 2,--NO 2, halo or lower alkylthio having one to four carbon atoms, and, each R' is independently selected from the group consisting of lower alkyl having one to six atoms, lower alkenyl having two to six carbon atoms, lower alkoxy having one to six carbon atoms, lower alkylthio or halo-lower alkyl having one to four carbon atoms, halo,--NO 2,--N(R 1) 2, STR2--NR 1 COR 2, and STR3 in which each R 1 is independently hydrogen or lower alkyl having one to four carbon atoms, or together form a piperidine or a piperazine ring optionally substituted at the ring nitrogen by lower alkyl having one to four carbon atoms or--CH 2 CH 2 OH, each R 2 is independently lower alkyl having one to four carbon atoms, A is an alkylene group if R is hydrogen, and the pharmaceutically acceptable acid addition salts thereof are useful as serine protease inhibitors in humans and animals.
