164025-47-2Relevant articles and documents
PIPERIDINE DERIVATIVES HAVING CCR3 ANTAGONISM
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Page/Page column 376, (2008/06/13)
The invention provides low molecular compounds having activity which inhibits binding of CCR3 ligands to CCR3 on target cells, i.e. CCR3 antagonists. The invention also provides compounds represented by formula (I) below, pharmaceutically acceptable acid adducts thereof, or pharmaceutically acceptable C1-C6 alkyl adducts thereof, as well as pharmaceutical compositions comprising them as effective ingredients, which are useful for treatment or prevention of diseases associated with CCR3, such as asthma and allergic rhinitis.
Synthesis of Novel Imidazobenzodiazepines as Probes of the Pharmacophore for "Diazepam-Insensitive" GABAA Receptors
Zhang, Puwen,Zhang, Weijiang,Liu, Ruiyan,Harris, Bradford,Skolnick, Phil,Cook, James M.
, p. 1679 - 1688 (2007/10/02)
The syntheses of a series of novel imidazobenzodiazepines and their affinities for diazepam sensitive (DS) and diazepam insensitive (DI) GABAA receptors are described.Imidazobenzodiazepines belong to one of the very few chemical families which