68707-69-7

Usage

Uses

Used in Pharmaceutical Industry:
2,3-DIMETHYL-4-NITROPYRIDINE is used as a chemical intermediate for the preparation of pyrrolo[3,2-b]pyridine derivatives, which are known as proton pump inhibitors. These inhibitors play a crucial role in the treatment of acid-related disorders, such as gastroesophageal reflux disease (GERD) and peptic ulcers, by reducing the production of stomach acid.

InChI:InChI=1/C7H8N2O2/c1-5-6(2)8-4-3-7(5)9(10)11/h3-4H,1-2H3

Upstream product

• 37699-43-7 2,3-dimethyl-4-nitropyridine N-oxide 

Downstream Products

• 163593-69-9 2,3-dimethyl-4-methoxypyridine 

Relevant academic research and scientific papers

PYRROLO[3,2-B]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF

The present invention provides novel pyrrolo[3,2-b]pyridine derivatives or pharmaceutically acceptable salts thereof, processes for the preparation thereof, and compositions comprising the same. The pyrrolo[3,2-b]pyridine derivatives or pharmaceutically acceptable salts thereof of the present invention have excellent proton pump inhibition effects and possess the ability to attain a reversible proton pump inhibitory effect.

Synthesis of New Substituted Quinolizidines as Potential Inhibitors of Ergosterol Biosynthesis.

Carbocationic species (High Energy Intermediates) have been postulated as intermediates in the course of enzymatic synthesis of ergosterol.Protonated aza-analogues of the sterol are thus potential inhibitors.The synthesis of substituted quinolizidines (3) is reported. 4-Methoxy-2,3-dimethylpyridine (4) was metalated and reacted with substituted 3-chloropropanal to build the 1-methyl-2-quinolizidinone.The lateral chain was prepared via a Wittig-Horner reaction.