163593-69-9Relevant academic research and scientific papers
Synthesis of pharmaceutically useful pyridine derivatives
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, (2008/06/13)
A process is provided for the preparation of compounds of formula I, useful in the preparation of compounds such as Omeprazole, Lansoprazole and Pantoprazole, wherein R1=H or CH3, R2=H or CH3, R3=Alkoxy (1-4C), OCH2CF3, Cyano, Hydrogen, Halogen, Acetoxy or Aryloxy, any electron withdrawing group or salts (organic or inorganic) of electron donating groups, R=Alkoxy, Hydroxy, Halogen, Activated ester, Tosylate, Mesylate, Thiol or Xanthyl, wherein the process for the preparation of compound of formula I employs a free radical reaction to functionalize the 2-position.
Synthesis of New Substituted Quinolizidines as Potential Inhibitors of Ergosterol Biosynthesis.
Godard, Alain,Lamour, Philippe,Ribereau, Pierre,Queguiner, Guy
, p. 3247 - 3264 (2007/10/02)
Carbocationic species (High Energy Intermediates) have been postulated as intermediates in the course of enzymatic synthesis of ergosterol.Protonated aza-analogues of the sterol are thus potential inhibitors.The synthesis of substituted quinolizidines (3) is reported. 4-Methoxy-2,3-dimethylpyridine (4) was metalated and reacted with substituted 3-chloropropanal to build the 1-methyl-2-quinolizidinone.The lateral chain was prepared via a Wittig-Horner reaction.
