68756-65-0Relevant academic research and scientific papers
Zirconocene-catalyzed direct (trans)esterification of acyl acids (esters) and alcohols in a strict 1:1 ratio under solvent-free conditions
Tang, Zhi,Jiang, Qiutao,Peng, Lifen,Xu, Xinhua,Li, Jie,Qiu, Renhua,Au, Chak-Tong
supporting information, p. 5396 - 5402 (2017/11/22)
A highly efficient way for the direct (trans)esterification of acyl acids (esters) and alcohols in a strict 1:1 ratio using a zirconocene complex (1, 1 mol%), a strong Lewis acid of good water tolerance, as a catalyst under solvent-free conditions has been developed. A wide range of acid and alcohol (esters) substrates undergo (trans)esterification to produce carboxylic ester motifs in moderate to good or excellent yields with good functional tolerance, such as that towards C-Br as well as CC and CC bonds. And complex 1 can be recycled six times without showing a significant decline in catalytic efficiency. It was demonstrated that cyclandelate, which is used to treat high blood pressure as well as heart and blood-vessel diseases, can be directly synthesized on a gram scale with 81% yield (6.70 g) using complex 1.
Rapid access to α-alkoxy and α-amino acid derivatives through safe continuous-flow generation of diazoesters
Bartrum, Hannah E.,Blakemore, David C.,Moody, Christopher J.,Hayes, Christopher J.
, p. 9586 - 9589 (2011/10/08)
Microreactors: A highly efficient continuous-flow process has been developed for the synthesis of diazoesters from arylsulfonylhydrazones by means of in-flow Bamford-Stevens reactions. Furthermore, a range of α-alkoxy and α-amino acid derivatives have bee
An efficient and convenient procedure for preparation of mandelates catalysed by TiO2/SO4/2- solid superacid
Jin,Ma,Li,Sun,Li
, p. 2051 - 2054 (2007/10/03)
An easy and efficient synthesis of mandelates in excellent yields from mandelic acid with alcohols catalysed by TiO2/SO42- solid superacid.
Fe2(SO4)3 · xH2O in synthesis: A new and convenient catalyst for the esterification of mandelic acid with alcohols
Zhang, Gui-Sheng,Gong, Hui
, p. 1547 - 1551 (2007/10/03)
Treatment of various of alcohols with mandelic acid in the presence of a catalytic amount of Fe2(SO4)3 · xH2O to give the corresponding esters in good yields.
A general and simple synthesis of phenylglyoxylic esters via the oxidation of mandelic esters with ammonium chlorochromate adsorbed on alumina
Zhang, Gui-Sheng,Gong, Hui
, p. 3149 - 3153 (2007/10/03)
A general method for preparation of phenylglyoxylic esters by oxidation of mandelic esters with readily available ammonium chlorochromate adsorbed on alumina is described.
